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Neo Resp Disease 1
RDS, TTNB,Pneumonia
| Question | Answer |
|---|---|
| RDS is AKA | Hyaline membrane disease |
| What is the etiology of RDS? | Prematurity of pulmonary system leading to a deficiency of surfactant production |
| 7 risk factors for RDS | premature, birth wt < 1200g, males, multiple gestations, prenatal maternal complications, maternal diabetes, placental and cord problems |
| 5 anatomical structures that are immature in an RDS neonate | terminal air sacs, pulmonary vasculature, cehst wall, respiratory muscles, and CNS |
| lack of stable surfactant in RDS neonate leads to what 6 things | atelectasis, hypoxia, hypercapnia, acidosis, damage to capillaries and alveolar wall |
| 5 Clinical signs for RDS | RR>60, grunting, retracting, flaring, cyanosis |
| Diagnosing RDS | maternal hx, shake test, ABG's, CXR, hypothermic, flaccid |
| RDS ABG's would show what 3 things | hypoxia, hypercapnia, mixed acidosis |
| How would a CXR appear in an infant with RDS | underaerated, opaque, "ground glass", air bronchograms |
| If an infant diagnosed with RDS dies after 72 hours what is it related to? | complications |
| RDS has shown to be prevented maternally if given what? | glucocorticoids for at least 24 hours before birth |
| What affect does glucocorticoids have? | produces more type II cells, more lamellar bodies in type II cells and stable surfactant |
| Tx of RDS | support pt/tx symptoms, O2, PPV, thermoregulation, surfactant administration |
| Complications from RDS include | BPD from long term vent use, IVH(interventricular hemorrhage) which occurs in 40% of those under 1500g, infections, and PDA (d/t hypoxemia) |
| 3 names of marketed surfactant and what they are made from | Curasurf-pigs, Survanta- cows, Infasurf-minced cow lung |
| What disease is AKA RDS type II? | ransient tachnypnea of the newborn (TTN, TTNB) |
| Etiology of TTNB | retention of fetal lung fluid, term or near term infants, cesarean or precipitous deliveries |
| Risk factors for TTNB | maternal sedation and asphyxia of the baby during labor/birth |
| Clinical signs of TTNB | RR>60-usually very high, signs of respiratory distress, cyanotic |
| Babies with TTNB abg's usually show what | hypoxia with normal CO2 |
| What would appear on the CXR of a baby with TTNB? | streaky infiltrates |
| Tx for TTNB | stabilize, tx symptoms, O2, NCPAP/ventilate, Positioning with CPT, Antibiotics |
| Why is there very few complications from TTNB | bc the fluid causing it usually clears in 2-48hrs and the infant makes a complete recovery |
| 3 ways a newborn can acquire Pneumonia | transplacental, perinatal, and postnatally |
| This type of bacteria cross the transplacental route | group B streptococci |
| 4 diseases that can cross transplacentally(ToRCH) | toxoplasmosis, rubella, cytolomegalovirus, Herpes |
| 4 maternal factors that could cause newborn to have pneumonia | PROM-ruptures membrane, infection, fever, stained amniotic fluid |
| Clinical signs of Pneumonia vary with organism but name a few generic signs | apnea, poor peripheral perfusion, tachycardia, lethargy, temp instability, hypotensive |
| Pneumonia ABG shows | hypoxia and hypercarbia (metabolic acidosis) |
| Pneumonia CXR would appear with what things present | diffuse granular pattern, patchy infiltrates, atelectasis |
| Tx for Pneumonia would include | aggresive mgmt, ABT or antivirals, support pt, O2/ventilation, ECMO |
| What signs would a neonate with pneumonia present with to determine if ECMO should be used | mottles, apneic, swinging BP's |
| This strain of streptococcus is most unresponsive to treatment | Group B |