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Pharm Ch 12 Dopa

Pharm LECOM Ch 12 Domamine Dopaminergic

QuestionAnswer
Mainstay Parkinson's treatment Levodopa
Levodopa administered in combo w/ carbidopa
D2 specific agonist Bromocriptine
D2 and D3 agonist Pergolide
D3 > D2 agonist Pramipexole
D3 > D2 agonist also used for Restless Leg Ropinirole
MAO-B inhibitor at low dose; doesn’t form toxic metabolite Rasagiline
MAO-B inhibitor at low does; forms toxic amphetamine Selegiline
Selegiline can cause these SA INSOMNIA AND CONFUSION
COMT inhibitor in CNS and periphery Tolcapone
COMT inhibitor that can cause hepatotoxicity Tolcapone
COMT inhibitor in periphery only Entacapone
Used to treat late Parkinson’s Levodopa induced dyskinesias Amantadine
mACh-R antagonist that treat Parkinsonian TREMOR Trihexyphenidyl, benztropine
Used to treat psychotic disorder, N/V Chloropromazine, Perphenazine
Treat psychotic disorder, CI with prolonged QT Thioridazine, Mesoridazine
5 most typical typical Antipsychotics Perphenazine, Thiothixene, Trifluoperazine, Chlorprothixene, Fluphenazine
Neuroleptic Malignant Syndrome symptoms Fever Encephalopathy Vitals unstable Elevated enzymes Rigidity of muscles
Use for psychoses and Tourettes & has q 4day IM injections Haloperidol
Use adjunct with anesthesia to reduce N/V droperidol
Typical antipsychotic Tx: psychotic disorders acts on ascending reticular formation molindone
Typical antipsychotic & Tx Tourettes, less sedation, will prolong QT Pimozide
Atypical psychotic mnemonic It is atypical for Old Clozets to Quietly Risper from A to Z
Atypical anti-psych + Bipolar SE: QT prolong, binds D2, 5-HT2, a1, a2, H1 Risperidone
Atypical anti-psych + Bipolar SE: QT prolong, D2/5-HT1A partial agonist, 5-HT2A antagonist aropirazole
Treats schizophrenia SE: agranulocytosis Binds D1-5, 5-HT2, a1, H1 Clozapine
Atypical anti-psych+ Bipolar Binds D1-4, 5-HT2, a1, H1, M1-5 Olanzapine
Atypical anti-psych+ Bipolar Binds D1-2, 5-HT2, a1, a2, H1 Quetiapine
Atypical anti-psych+ Bipolar SE: QT prolong CI: MI, arrhythmia, floxacins, HF Binds D2, 5-HT1-2, a1, H1 ziprasidone
Created by: csheck
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