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Chapter 11: OA
Opioid analgesics
| Question | Answer |
|---|---|
| Agonist | A substance that binds to ther receptor and casues a response |
| Agonist-antagonists | (partial agonist) bind to the receptor and cause a partial response that is not as strong as one made by an agonist |
| Analgesic ceiling effect | occurs when a given pain drug no longer effectivly controls a patients pain despite the administration of the highest dose |
| Analgesics | Relieve pain w/o causing loss of conciousness |
| Break through pain | Pain that occurs btwn doses of pain medications |
| Gate theory | gate model to explain how impulses from damaged tissues are sensed in the brain. Found on the dorsal horn of the spinal cord |
| Neuropathic pain | Pain that results from the disturbance of function of pathogenic charge in a nerve, damage to peripheral of CNS fibers by disease or injury |
| Nociception | processing of pain signals in the brain that gives rise to feeling. |
| Nociceptors | subclass of sensory A and C nerve fibers that transmit pain signals to the CNS |
| NSAIDs | A lg chs and chemically diverse group of drugs that are analgesic and antiinflammatory and antipyretic (prevent fever) acivity but are NOT steroids |
| Opiod analgesics | synthetic drugs that bind with opiate receptors to relieve pain but are not themselves derived from the opium plant |
| Opiod naive | describes patients who are recieveing opiod analgesics for the first time and who therefor are not accustomed to their effects |
| Opiod tolerance | opposit of opiod naive. patients who have recieved opiod analgesics and are therefore at a greater risk of withdrawl when they stop |
| Referred pain | ocurring in the area away from the organ of origin |
| Somatic pain | skeletal muscles, ligaments, or joints |
| Vascular pain | results from a pathology of the vascular or perivascular tissue *migraine |
| Visceral pain | Pain that originates from organs or smooth muscles |