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Pharm Ch 8 Cholinerg

LECOM Pharm Ch 8 Cholinergic

QuestionAnswer
Prevents Ach vesicle fusion and release by degrading synaptobrevin Botulinum Toxin
Short acting AChE inhibitor used for myasthenia gravis Dx edrophonium
Use for atropine overdose w/ good CNS & glaucoma penetration physostigmine
AChE inhibitor used for best increased GI motility etc Neostigmine
Long..er acting AChE inhibitors Neostigmine, Pyridostigmine, Ambenonium
AChE Inhibitor used for AD associated w/ hepatotoxicity Tacrine
“pseudo irreversible” AChE inhibitor used for AD Rivistigmine
Longest half-life of AChE inhibitors used for AD Donepazil
Muscarinic agonist used for asthma Dx Methacholine
Methacholine contraindications MI, HTN stroke, aneurysm
Muscarinic Agonist selective for CV receptors Methacholine
Decrease urinary retention post surgery bethanechol
Topical glaucoma treatment both mACh & nACh carbachol
Used to treat Xerostomia in Sjogren’s syndrome pilocarpine & Cevemeline
Depolarizing NMJ- blockading agent succinylcholine
Don’t use this paralytic with cranial injuries succinylcholine
Paralytic that can cause cardiac arrest succinylcholine
Succinylcholine can cause what electrolyte imbalance hypercalcemia & hyperkalemia
Prototypical mAChR antagonist atropine
Treatment of choice for organophosphate poisoning atropine
Atropine side effects hot, dry, red, blind, “mad as a hatter” constipated, decrease gut acid
Treats motion sickness with CNS side effects scopolamine
Added to PUD treatment pirenzapine, methscopalamine, glycopyrrolate
Treats surgically or vagally induced bradycardia glycopyrrolate
Treats COPD>asthma ipratropium & <tiotropium
Non-specific mAChR antagonists used for GU hyperactivity oxybutynin, propantheline, tolteradine, trospium
M3AChR Antagonists that treat GU hyperactivity darafenicin, solifenacin
Long acting non-depolarizing paralytics Pancuronium & tubocuronium
Intermediate acting non-depolarizing paralytics vecuronium & rocuronium
Short acting non-depole paralytic mivacuronium
Drops BP and blocks sympathetics in AAA trimethaphan & mecamylamine
Created by: csheck
Popular Pharmacology sets

 

 



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