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PHARM CHARM VI

Exam 2

QuestionAnswer
Actions of Aspirin that are believed to depend on aspirin's ability to inhibit cyclooxygenase include: Anti-inflammatory (reduces infl) antipyretic (fever reducer) Analgesic (pain reliever)
what drug is used to treat (alleviate) an acute attack of gout? Colchicine
Which of the following statements about acetaminophen is FALSE? Patients allergic to aspirin are cross allergic to acetaminophen
A patient has had serious anaphylactoid allergic reaction to NSAID,naproxen[Naprosyn]. Which of the following analgesics would be contraindicated? Aspirin
The drug suggested for the prevention of migraine headache is: [Inderal] Propranolol
Which drugs appear to stop or partially reverse joint destruction in patients with rheumatoid arthritis? Immunosupressants (Methotrexate)
the result of an electrical signal sent to a person's brain upon injury,the affected tissue releases chemicals or hormones called prostaglandins PAIN
Prostaglandins cause tissue to swell when what happens? PAIN
can be accomplished by reducing the release of peripheral endogenous pain-producing substances w/nonsteriodal anti-inflamm drugs,or NSAIDs Pain reduction
if you impair the awareness of pain and response to incoming noxious stimuli with opioids, you reduce what? Pain
acetylsalicylic acid or ASA PROTOTYPE of SALICYLATES (NONOPIOID) Analgesic Antipyretic Anti-inflammatory inhibits platelet aggregation Aspirin
nausea and vomiting are caused by ___? Aspirin
nonsteroidal Anti-Inflammatory drugs Non-Aspirin NSAIDs Ibuprofen
Non-OPIOID SALICYLATE Aspirin
Prototype of Non-Aspirin NSAIDs Ibuprofen, Motrin, Advil
side effects: nausea and vomiting Ibuprofen
MOA: inhibit COX (cyclooxygenase) enzymes interfering w/synthesis of prostaglandins. Aspirin and Ibruprofen
a selective COX-2 inhibitor provides relief of inflammation and pain due to... Osteoarthritis and Rheumatoid Arthritis with fewer ulcers no effect on platelet aggregation...like aspirin [CELEBREX] Celecoxib
side effects: abdominal pain diarrhea dyspepsia [Celebrex] side effects
Fluconazole all NSAIDS Celebrex drug interactions
drugs used for arthritis drug is slowly excreted possib bone marrow supression and liver damage Treats: discoid & systemic lupus or acute/chronic rheumatoid arthritis [Plaquenil} Hydroxychloroquine
drugs used for arthritis teratogenic cause hepatic toxicity bone marrow supression severe GI ulceration [RHEUMATREX] Methotrexate
"Slow acting disease modifying antiheumatic drugs" DMARDs
must be started b4 major joint destruction has occurred. Have potentially serious adverse affects onset and offset delayed weeks DMARD Drugs
treats arthritis and synovitis drugs suppress phagocytosis and lysomal activity stop or partially reverse joint destruction Gold compounds
the most common adverse rxn is skin rash oral: diarrhea can cause bone marrow depression and kidney damage Gold compounds
drugs used for arthritis (rheumatoid) Treats tissue necrosis Factor modifiers [Arava]-A
contraind in patients w/hepatic insuff half-life = 2 weeks or 14 days or 336 hours [Arava]-A
drugs used for Arthritis tissue necrosis Factor modifiers like Arava [Eubel]-A
drugs for GOUT Drugs for hyperuricemia Colchicine-G
treats mostly acute gout arthritis or acute gout attacks Colchicine-G
teratogenic drug should be stopped if diarrhea begins bc this can cause profound diarrhea nausea/vomiting dehydration shock Colchicine-G
drugs for Gout drugs for hyoeruricemia URICOSURIC increases urinary excretion Benemid-G
may cause GI upset patients taking this drug should be well hydrated Benemid-G
drugs used to treat GOUT hyperuricemia treats patients who are excessive uric acid producers Zyloprim-G
preferred drug in patients w/impaired renal fxn causes GI upset and Rash patients should drink plenty H20 Zyloprim-G
drugs for migraines causes vasoconstriction supresses the release of compounds that promote release of inflamm neuropeptides Imitrex-M
dizziness life threatening arrythmias warm tingling feeling dysphagia/abdominal discomfort IMITREX-M
available as a nasal spray injection provides relief in 10 min tablets rapidly dissolving tablets IMITREX-M
drugs for MIGRAINES preferred drug for prophylaxis prevents vasodilation Propranolol-M
OPIOID reduces pain and emotinal rxn to pain when given PO most if this drug is metabolized in liver metabolites excreted via kidney MORHINE-O
well absorbed from sites of admin although some have large first pass effect OPIOID
relief from moderate-severe pain ventilator control special anesthesia preop and postop pain relief treats diarrhea relief of cough Morphine-O
can cause death in resp depression TRIAD symptoms: pin point pupils,resp depression,loss of consciousness with decr BP Morphine-O
sedation drowsiness ataxia euphoria nausea/vomiting decr resp or depth of resp hypotension bradycardia constip urinary ret prolonged labor makes uterus contract MORPHINE-O
OPIOID synthetic-similar to morphine shorter duration than morphine DEMEROL-O
contined use may cause toxic metabolites IM injection avail as tablet DEMEROL-O
OPIOID used for CHRONIC-SEVERE pain prescr as a lozenge for cancer pain FENTANYL-O
Avail parenteneal transdermal transmicosal Fentanyl-O
OPIOID Centrally acting synthetics pain reliever metab to active form by Cyto p450 SOUTHERN CHINESE do not benefit from this drug inhibits reuptake of NE and Serotonin TRAMADOL [Ultram]
contraind: liver disease patients ppl taking CNS depressants or MAO inhib TRAMADOL
dizziness nausea constipation headache somnolence TRAMADOL
MORPHINE DEMEROL FENTANYL TRAMADOL OPIOID (4)
Propranolol IMITREX Migraine Drugs (2)
ZYloprim Benemid Colchicine GOUT drugs (3) Zavier's Breakfast "GOUT/got" Cold!
Celebrex Ibruprofen NSAIDs (2)
EUBEL ARAVA Rheumatrex Plaquenil Arthrtis drugs (4)
Created by: boomer_bevo
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