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pht 101 c5p7
chapter 5 part 7
| Question | Answer |
|---|---|
| Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Prevent | replication of HIV |
| Nucleoside Reverse Transcriptase Inhibitors (NRTIs) like these should be taken alcoholic beverage free | abacavir (Ziagen), didanosine (Videx) should be taken on an empty stomach, emtricitabine (Emtriva), lamivudine (Epivir), stavudine (Zerit), & zidovudine, AZT (Retrovir) |
| Side Effects of NRTIs are | GI distress is common, Nausea, diarrhea, abdominal pain, Usually improves within first 2 weeks of therapy & More permanent side effects of NRTIs include degeneration of the liver |
| NRTIs are | Taken with or without food, Generally do not interfere with other drugs, & Administered in two or three doses per day |
| lamivudine (Epivir) is Used for | HIV and chronic hepatitis B |
| lamivudine (Epivir) Must be taken | exactly as prescribed |
| lamivudine (Epivir) has Fewest side effects of | any of the NRTIs |
| zidovudine, AZT (Retrovir) was One of the first drugs | for HIV treatment |
| zidovudine, AZT (Retrovir) Can be combined with | all NRTIs Except stavudine |
| zidovudine, AZT (Retrovir) is Used in combination with | lamivudine (with or without PI) for needlestick or sexual exposure |
| Do not use the abbreviation AZT for zidovudine because | Use of abbreviation can lead to medical errors |
| Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) Inhibit action of | HIV reverse transcriptase |
| Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) | delavirdine (Rescriptor), efavirenz (Sustiva), & nevirapine (Viramune) |
| efavirenz (Sustiva) is Dosed | once a day, prefer bedtime |
| Avoid high-fat meals when taking | efavirenz (Sustiva) |
| Side effects of efavirenz (Sustiva) are | Dizziness, headache, Vivid dreams, nightmares, hallucinations, Typically 1 to 3 hours after administration, & Usually subside after 2 to 4 weeks on drug |
| nevirapine (Viramune) should be taken | in a Lower dose first 2 weeks, then increased to therapeutic level to avoid rash |
| Antibiotic rifampin interferes with | nevirapine (Viramune) |
| nevirapine (Viramune) Decreases | serum concentration of PIs |
| Must monitor liver functions when taking | nevirapine (Viramune) |
| nevirapine (Viramune) may interfere with | b.c. pills |
| Nucleotide Reverse Transcriptase Inhibitor (NtRTIs) Mimics a DNA building block to stop | formation of DNA copy |
| Theres Less toxicity in NtRTIs than | in NRTIs |
| another Nucleotide Reverse Transcriptase Inhibitor (NtRTIs) is | tenofovir (Viread) and should be taken |
| Protease Inhibitors (PIs) Inhibit protease enzyme, which cleaves certain | HIV protein precursors needed to replicate virus |
Created by:
moekah
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