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pht 101 c5p6
chapter 5 part 6
| Question | Answer |
|---|---|
| zanamivir (Relenza) is Used for | influenza A and B |
| zanamivir (Relenza) Taken within | 48 hours of onset of symptoms with 2 inhalations daily, 12 hour intervals, for 5 days |
| If using bronchodilator, use immediately prior to | administration of zanamivir |
| zanamivir (Relenza) is Sometimes | prophylactic |
| ganciclovir (Vitrasert) is a | Ophthalmic antiviral |
| ganciclovir (Vitrasert) is Available in | oral and IV form |
| Pregnant women should not handle this ganciclovir (Vitrasert) and | there’s a chemo precaution |
| virus | a minute infectious agent that does not have all the components of a cell and thus can replicate only within a living host cell |
| virion | an individual viral particle capable of infecting a living cell; consists of nucleic acid surrounded by a capsid (protein shell) |
| capsid | a protein shell that surrounds and protects the nucleic acid within a virus particle |
| envelope | membrane around the capsid in some viruses & carrying surface proteins that attach to cell surface receptors |
| naked virus | a virus without an envelope covering the capsid |
| flu | a common viral infection; influenza |
| hepatitis | a disease of the liver that causes inflammation, can be acute or chronic, and has several forms A-G |
| human immunodeficiency virus (HIV) | a retrovirus transmitted in body fluids that causes AIDS by attacking T lymphocytes |
| acute viral infection | an infection that quickly resolves with no latent infection |
| chronic viral infection | an infection that has a protracted course with long periods of remission interspersed with recurrence |
| slow viral infection | an infection that maintains a progressive course over months or years with cumulative damage to body tissues, ultimately ending in the host's death |
| local viral infection | an infection affecting tissues of a single system such as the respiratory tract, eye, or skin |
| generalized viral infection | an infection that spreads to other tissues by way of the bloodstream or the central nervous system |
| latency | the ability of a virus to lie dormant and then, under certain conditions, reproduce and again behave like an infective agent, causing cell damage |
| immunoglobulin | an antibody that may prevent an organism from attaching to a cell receptor and may destroy the organism |
| interferon | a substance that exerts virus-nonspecific but host-specific antiviral activity by inducing gene coding for antiviral proteins that inhibit the synthesis of viral RNA |
| vaccination | the introduction of a vaccine, a component of an infectious agent, into the body to produce immunity to the actual agent |
| antiviral | agents that prevent virus replication in a host cell without interfering with the host's normal function |
| prodrug | a compound that on administration and chemical conversion by metabolic processes becomes an active pharmacological agent |
| HIV is a retrovirus which | Copies its RNA genetic information into the host’s DNA, Uses reverse transcriptase, a retroviral enzyme, & Antiretroviral drugs limit progression of HIV retrovirus |
| Seven Classes of Antiretroviral Drugs are | Nucleoside reverse transcriptase inhibitors (NRTIs), Non-nucleoside reverse transcriptase inhibitors (NNRTIs), Nucleotide reverse transcriptase inhibitors (NtRTIs), Protease inhibitors, Fusion inhibitors, Chemokine receptors, & Integrase inhibitors |
| Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Mimic a DNA building block to inhibit | the actions of the enzyme nucleoside reverse transcriptase |