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Pharm - Ch. 17

Adrenergic Agonists

QuestionAnswer
Adrenergic agonists are also called _____ Sympathomimetics
Most adrenergic agonists act by ____ activation of adrenergic receptors Direct
What are indirect mechanisms of activating adrenergic R? Promotion of NE release, blockade of NE uptake, inhibition of NE breakdown
Activation of alpha1 receptors causes Vasoconstriction and mydriasis
Alpha1 agonists are used for... Hemostasis, nasal decongestion, elevation of BP, and adjuncts to local anesthetics
What are major adverse effects of alpha1 activation? Hypertension, local necrosis (due to extravasation)
Drugs activating alpha2 receptors in which NS is used to clinically treat hypertension and severe pain? CNS
All clinically relevant responses to beta1 R activation result from activation in ___ Heart
What are the effects of beta1 receptor activation in heart? Inrease HR, force of contraction, conduction through AV node
Drugs activating beta1 receptors used to treat what? Heart failure, AV block, cardiac arrest
What are some adverse effects of beta1 activation? Tachycardia, dysrhythmias, angina
Beta2 agonist drugs used to treat ___ and prevent ___ Asthma and preterm labor
Main adverse effects of beta2 activation? Hyperglycemia in diabetics, tremor
Epinephrine is activates which receptors? Alpha1, alpha2, beta1, beta2
What drug is used for anaphylactic shock? Epinephrine. BP elevated through alpha1, beta1, beta2. Bronchodilation. Used to control superficial bleeding, restart heart after cardiac arrest, and delay absorption of local anesthetics
Epinephrine is administered through which routes? Topically or by injection
What kind of drug is destroyed by enzymes before reaching systemic circulation? Catecholamine such as epinephrine
Created by: choel
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