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pht 101 c5p1
chapter 5 part 1
| Question | Answer |
|---|---|
| Fungi are Single-cell organisms like | Mushrooms, yeasts, and molds |
| Eukaryotic (defined nucleus) | fungus, animal cell, and green plant cell |
| Prokaryotic (no defined nucleus) | bacteria |
| Fungi differ from green plants because they | Lack chlorophyll & they Reproduce by spores |
| Fungi Have rigid cell wall unlike | that of bacteria |
| In what ways are human cells fungi different from cells? | Human cell membranes contain cholesterol, and cell membranes of fungi contain ergosterol. |
| Systemic fungal diseases most likely to occur in | immunosuppressed by disease or drug therapy (corticosteroids or antineoplastics) |
| Fungi can cause | skin and nail infections |
| Women on antibiotics often need | antifungal for vaginal yeast infection |
| Aspergillus causes | aspergillosis |
| Blastomyces causes | blastomycosis |
| The yeast candida causes | candidiasis |
| Coccidioides causes | coccidioidomycosis |
| Cryptococcus causes | Cryptococcus causes |
| Histoplasma causes | histoplasmosis |
| Antifungals have | amphotericin B (Abelcet (ABLC), AmBisome, Amphocin, Amphotec, Fungizone), clotrimazole (Mycelex), flucytosine (Ancobon), griseofulvin (Fulvicin P/G, Gris-PEG, ketoconazole (Nizoral), nystatin (Mycostatin), terbinafine (Lamisil), & terconazole (Terazol) |
| Antifungals have Echinocandin like | anidulafungin (Eraxis), caspofungin (Cancidas), & micafungin (Mycamine) |
| Antifungals have Triazole like | fluconazole (Diflucan), itraconazole (Sporanox), posaconazole (Noxafil), & voriconazole (VFEND) |
| Antifungals Prevent synthesis of | ergosterol, building block for fungal cell membranes |
| Human cell membranes Use | cholesterol & are Affected minimally by antifungals |
| Antifungals Inhibit fungal cytochrome P-450 are Different from | human P-450 & Have little effect on human cells |
| Antifungals destroys | fungi |
| Antifungals have Three forms | Topical agents, IV agents, & Systemic agents |
| There are Reports of serious | side effects, even for topical agents |
| Pay close attention to dosing regimen to avoid | overdosing Antifungals |
| amphotericin B (Fungizone) are | Used for blood-born, life-threatening fungal infections |
| Blood levels of amphotericin B (Fungizone) are | monitored and vitals checked during infusion |
| amphotericin B (Fungizone) is Infused | slowly. Not piggybacked, not mixed with normal saline |
Created by:
moekah
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