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PNS-cholingeric

PNS-cholingeric drugs

QuestionAnswer
Muscarinic Agonists Promoting parasympathetic responses
Bethanechol/Urecholine -Activates Muscarinic receptors in urinary tract, increase tone of smooth muscles & sphincters -Relieves urinary retention
Pilocarpine -Allows aqueous humor to drain -Topical therapy of glaucoma
Muscarinic Poisoning -Caused by mushrooms, muscarinic agonists, Cholinesterase inhibitors -Antidote: Atropine
Muscarinic Antagonists Anti-parasympathetic
Atropine -Increases heart rate-bradycardia -Decreases secretions -Dilates the pupil -CNS excitation
Neostigmine/Prostigmine Bromide -Prevents the inactivation of ACh -Affects muscarinic and nicotinic-m -Promotes parasympathetic and muscle activity
Physostigmine -For muscarinic antagonist poisoning (atropine)
Donepezil/Aricept -Used for Alzheimer’s Disease -Inhibit breakdown of ACh in CNS -Helps the healthy cells transmit better
Cholinesterase Inhibitors -Enhance the action of ACh/parasympathetic -Irreversible-very long lasting effects -Antidote - Pralidoxime/Protopam
Neuromuscular Blocking Agents -Block acetylcholine from activating nicotinicM receptors on skeletal muscles -Cause muscle relaxation
Created by: asr1a1
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