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PHM 101

Chapter 9- Compounding

QuestionAnswer
List at least 4 reasons for compounding? 1. Pediatric patients requiring diluted adult strengths of drugs 2. Specialized dosages for therapeutic drug monitoring. 3. Compounding for animals 4. Hospice patients for pain
Who is compounding regulated by? The State Boards of Pharmacy and US Pharmacopeia
What are some personnel regulations on compounding in a pharmacy? Pharmacy responsibility to manage. List of qualifications pharmacist must have to compound and recommends further education
What are some facilities and equipment regulations on compounding in a pharmacy? Compounding area must have designated are away from "routine dispensing and counseling functions and high traffic areas" of the pharmacy. Recommended equipment
What is the lowest grade of purity for chemicals used in compounding? USP or NF grade
What is quality assurance? QA- Program of activities used to assure that the procedures used in compounding a product lead to products that comply with specifications and standards
What is quality control? QC- Set of testing procedures that determine the quality of the compounded formulation
What are some documentations and record keeping that must be done for compounding? A formulation record- Recipe. A compounding record- What actually happened when formulation was compounded. Standard operating procedures- SOPs Material safety data sheets- MSDs
What is the Beyond-Use Date for nonaqueous liquids and solid formulations? 25% of the time remaining until the drug product's expiration date or 6 months. Which ever comes first
What is the Beyond-Use Date for water containing formulations? No later than 14 days when stored at cold temp
What is the sensitivity of a Class A balance? Up to 6 mg
What is the capacity of a Class A balance? Minimum weighable quantity of 120 mg of material with a 5% error. Maximum weighable quantity of 60 grams
How must the weights be handles with a Class A balance? With forceps to prevent soiling and erosion of the weights
What is the weighing quantities of an electronic balance? Smaller than 120 mg
What is the sensitivity of an electronic balance? Around 1 mg
How often should weighing papers or weighing boats be used? With each new drug to prevent contamination
What is the abbreviation of "to deliver"? TD
What is the abbreviation of "to contain"? TC
What is the best type of graduated cylinder to use? Cylindrical graduated cylinder because it is more accurate
What sizes to syringes usually come in? From 0.5 ml to 60 ml and in a variety of materials and styles
What measuring equipment are not volumetric? Erlenmeyer flasks. Beakers. Prescription bottles
What is important when selecting a liquid measuring device? Always use smallest device that accommodates volume. Use calibrated pipet, micropipet, or syringe to measure less than 1 ml. Read measurement by meniscus
What is important when using graduated cylinders? Place on flat surface. Hold solution with right hand. As liquid approaches desired amount slow pouring. Transfer liquid to appropriate vessel allowing about 15 s to drain
What type of syringe will not take a needle? Oral syringes because not sterile
What are aqueous solutions? Clear but not always colorless liquids in which the drug is completely dissolved
What are syrups? Concentrated or nearly saturated solution of sucrose in water
What are nonaqueous solutions? Solutions that contain solvents other than water, either alone or in addition to water
What is the main solvent for nonaqueous solutions? Alcohol
What are suspentions? Two phase system consisting of a finely divided solid dispersed in a liquid- usually water
Created by: Tara3184
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