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PHM1810 Chp 3
Pharmacology 1, Chapter 3: Biopharmaceutics, De More
| Question | Answer |
|---|---|
| absorption | the movement of a drug from its site of administration into the bloodstream |
| active transport | process that moves particles in fluid through membranes from a region of lower concentration to a region of higher concentration |
| agonist | drug that performs a functional change in a cell |
| anaphylactic reaction | a servere, life-threatening allergic reaction to a drug |
| antagonist | drug that blocks a functional change in a cell |
| antimetabolite | a substance that is produced to alter the actions of liver enzymes |
| bioavailability | measurement of the rtae of absorption and total amount of drug that reaches the systemic circulation |
| biotransformation | the conversion of a drug within the body; aka metabolism |
| diffusion | process of particles in a fluid moving from an area of higher concentration to an area of lower ocncentration resulting in even distribution of particles in the fluid |
| dose-effect relationship | relationship between drug dose and blood or other biological fluid concentrations |
| drug clearance | elimination rate over time divided by the drug's concentration |
| excretion | process by which undigested residue of food and waste products from metabolism are eliminated from the body |
| filtration | the movement of water and dissolved substances from the glomerulus to the Bowman's capsule |
| first-pass effect | drugs reaching the liver where they are partially metabolized before being sent to the body |
| glomerular filtration rate (GFR) | rate of filtration in the kidneys |
| half-life | time it takes for the plasma concentration of a drug is reduced by 50% |
| hepatic portal circulation | circulation of blood through the liver |
| idiosyncratic reaction | experience of a unique, strange, or unpredicted reaction to a drug |
| lipid soluability | ability to dissolve in a fatty medium |
| passive transport | most common and important mode of transport through membranes; done by diffusion |
| pharmacodynamics | study of the biochemical and physiological effects of drugs |
| pharmacokinetics | study of the absorption, distribution, metabolism and excretion of drugs |
| placebo | sugar pill |
| reabsorption | movement of water and selected substances from tubules to peritubular capillaries (kidney) |
| target sites | areas where a drug's greatest action takes place at the cellular level |
| tolerance | reduced responsiveness of a drug because of adaptation to it |
| tubular secretion | the active secretion of substances such as potassium from the peritubular capillaries into the tubules (kidney) |
Created by:
MrsAFlaherty
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