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Autonomic Drugs
Drugs and classes
| Question | Answer |
|---|---|
| Neostigmine | Cholinergic Agonists (AChE Inhibitors) |
| Neostigmine | Increase Bladder Motility Treat Myasthenia gravis reverse NM blockade |
| Physostigmine | Cholinergic Agonists (AChE Inhibitors) |
| Physostigmine | Glaucoma Atropine Overdose |
| Edrophonium | Cholinergic Agonists (AChE Inhibitors) |
| Edrophonium (tensilon) | dx of myasthenia gravis |
| Organophosphates | Cholinergic Agonists (AChE Inhibitors) |
| Echothiophate, DFP, Soman, sarin, tabum, parathion, malathion | organophosphates |
| 2-PAM | muscarinic antagonist (use within 3 hrs) |
| Atropine | muscarinic antagonist |
| Ipratropium | muscarinic antagonist |
| Tiotropium | muscarinic antagonist |
| Ipratropium | COPD/acute asthma attacks |
| Tiotropium | COPD/acute asthma attacks |
| Tolteridine | muscarinic antagonist |
| Tolteridene | used to treat overactive bladder |
| Lomotil | Atropine + opioid to treat diarrhea |
| Tropicamide | muscarinic antagonist |
| Homatropine | muscarinic antagonist |
| Tropicamide | mydriasis |
| Homatropine | mydriasis |
| Atropine | Low dose- salivary glands, sweat glands, bronchioles high dose- GU/GI CNS at high doses |
| Atropine | muscarinic antagonist |
| Scopolamine | muscarinic antagonist |
| Scopolamine | Motion sickness |
| Phenlyepherine | Alpha 1 agonist |
| Clonidine | alpha 2 agonist |
| Dobutamine | beta 1 agonist |
| albuterol | beta 2 agonist |
| NE | pulse pressure unchanged |
| Epi | pulse pressure increased |
| Epi | low dose- vasodilation (beta) high dose- vasoconstriction (alpha) |
| Epi | vasocontrictor- for anaphylactic shock bronchodilator- for severe asthma attack |
| Ephedrine | decongestant hypotensive emergency |
| pseudoephedrine | decongestant mydriasis |
| clonidine | alpha 2 agonist decreases sympathetic output decreases peripheral resistance and CO treat HTN |
| Isoproterenol | beta 1 & 2- increased rate and contraction of heart, vasodilation |
| Dobutamine | beta 1 agonist increased contractility of heart used for stress testing |
| Dopamine | treat cardiac shock |
| Amphetame/tyramine/cocaine/antidepressants | increased NE |
| phentolamine | alpha antagonist (1 & 2) |
| phentolamine | decrease peripheral resistance and BP reflex tachycardia alpha 2 block increases NE release, more tachycardia |
| phenoxybenzamine | alpha antagonist |
| phenoxybenzamine | irreversible alpha blockade used for pheochromocytoma |
| prazosin | alpha antagonist (Alpha 1) vasodilation less tachycardia (no alpha 2 block) |
| terazosin, doxazosin | alpha 1 blockers tx for BPH postural hypotension |
| Tamsulosin | alpha 1A antagonist BPH |
| Yohimbine | alpha 2 antagonist increases NE release |
| propanolol | non-selective beta blocker |
| propanolol | decreases mortality after MI treat angina CHF bronchoconstriction |
| timolol | glaucoma caution in asthma |
| metoprolol | beta-1 selective blocker |
| atenolol | beta-1 selective blocker |
| bisoprolol | beta-1 selective blocker |
| nebivolol | beta-1 selective blocker |
| esmolol | beta-1 selective blocker |
| betaxolol | beta-1 selective blocker |
| nebivolol | vasodilation due to NO release |
| esmolol | short acting |
| betaxolol | glaucoma safer than timolol, less bronchoconstriction |
| Labetalol | beta and alpha blocker for HTN emergency decreases peripheral resistance (alpha 1 block) and prevents tachycardia (beta 1 block) |
| carvedilol | beta and alpha blocker for HTN emergency decreases peripheral resistance (alpha 1 block) and prevents tachycardia (beta 1 block) |
| pindolol | beta blocker with ISA |
| carteolol | beta blocker with ISA |
| penbutolol | beta blocker with ISA |
| acebutolol | beta blocker with ISA |