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BMS60048

Drugs acting on Serotonin Receptors and Pumps

QuestionAnswer
what is the only ionotropic 5-HT receptor? 5-HT3
5-HT 1A receptors (agonist/antagonists; suffix; tx) agonist; -pirones and -pidil; anxiety and hypertension
5-HT 1D/1F receptors (agonist/antagonists; suffix; tx) agonist; -triptans; migranes
5-HT 2 receptors (agonist/antagonists; tx) antagonist; psychosis
5-HT 3 receptors (agonist/antagonists; suffix; tx) antagonist; -setrons; emesis
5-HT 4 receptors (agonist/antagonists; suffix; tx) agonist; -prides; gastroparesis
urapidil 5-HT 1A agonist; alpha1 receptor antagonist => vasodilation, lowers BP
buspirone 5-HT 1A partial agonist; also has some D2 and weak 5-HT2 affinity; anti-anxiety and restlessness; onset of effect is slow and full effect may take months; not useful for acute attacks but good for long term; low chance of addiction
triptans 5-HT1 D/F agonist; b/f - arterial/cerebral vasoconstriction; d - reduce nociceptive transmission (inflammatory soup); used for migraines
what is the first generation triptan? sumatriptan
what is the major difference between the later generation triptans and the older ones? the later generations have longer t1/2
which triptan is not metabolized via MAO-A? naratriptan with CYP450
Created by: cbart004
Popular Pharmacology sets

 

 



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