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BMS60044

Drugs acting on calcium channels

QuestionAnswer
L type drugs verapamil, diltiazem, nifedipine; -pamil, -dipine
T type drugs mibefradil, ethosuximide, methsuximide, zonisamide, valproate, phenytoin
PQRN drugs Gabapentin, pregabaline
Selectivity of verapamil (myocardial vs vascular) 1:1
Selectivity of diltiazem(myocardial vs vascular) 1:5
Selectivity of nifedipine(myocardial vs vascular) 1:15
Selectivity of felodipine and nimodipine(myocardial vs vascular) 1:>10
What Vaughan-Williams class are Ca channel blockers? Class IV
verapamil decreases HR and O2 demand; contraindicated in AV conduction;get constipation,oedema, increases digoxin levels
nifedipine MAIN ACTION: LOWERS BP; arteriolar>> (vein); vasodilator, decreases afterload, orally, short t1/2 --> frequent dosing, increases HR
felodipine and nimodipine same as nifedipine but have long t1/2
diltiazem lowers HR and O2 demand (less than verapamil; used for coronary artery vasospasm relief (variant angina)
mibefradil Ca channel blocker; taken off the market due to drug-drug interactions
ethosuximide used for absence (petit mal) seizures
methsuximide similar to ethosuximide
zonisamide mixed MOA; used in chronic pain tx
valproate mixed MOA; oldest t-type channel blocker
phenytoin Na and Ca channel blocker; anti-seizure; SE: gum hyperplasia, megaloblastic anemia, folate deficiency; zero order kinetics; 3A4 inducer
gabapentin and pregabalin alpha-2/delta 1&2 ligands; reduce transmitter release
dantrolene given i.v.; RyR receptor blocker; used for malignant hyperthermia; inhibits the release of intracellular Ca from skeletal muscle SR
Created by: cbart004
Popular Pharmacology sets

 

 



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