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BMS60043

Drugs acting on chloride channels (GABA receptor)

QuestionAnswerClinical EffectsClinical EffectsClinical Effects
Endogenous Antagonists carbolines
Exogenous Agonists benzodiazepines (BDZ); barbiturates, propofol, alcohol
Benzodiazepines (BDZ) attach to the alpha subunit; work only when GABA is present sedative, hypnotic, amnesic,muscle tone decrease, anti-epileptic; no analgesia
-zepam BDZ
-zolam BDZ
Short Acting BDZ TOMB: Triazolam Oxazepam Midazolam Brotizolam
Intermediate Acting BDZ LETAL: Lorazepam Estazolam Temazepam Alprazolam Loprazolam
Long Acting BDZ Diazepam Flurazepam Clotiazepam Nitrazepam Flunitrazepam
Which BDZ don't do Phase I metabolism? TOL: Temazepam Oxazepam Lorazepam
non-BDZ hyp Zaleplon Zolpidem Zopiclone
BDZ antagonist Flumazenil
Barbiturates and Profolol beta subunit; work without GABA; no analgesia
Barbiturates sedative-hypnotics (anesthesia) anti-epileptic
thiopental sedative-hypnotic barbiturate
phenobarbital anti-epileptic barbiturate
profolol sedative hypnotic anesthesia
vigabatrin inhibits GABA transaminase, decreases GABA metabolism, increases GABA anti-epileptic
Tiagabin GABA-reuptake inhibitor; increases GABA anti-epileptic
Gabapentin not a GABA agonist;alpha-2 delta ligand at PQRN-Ca channel; decreases transmitter release
Baclofen
Endogenous Antagonists carbolines
Exogenous Agonists benzodiazepines (BDZ); barbiturates, propofol, alcohol
Benzodiazepines (BDZ) attach to the alpha subunit; work only when GABA is present sedative, hypnotic, amnesic,muscle tone decrease, anti-epileptic; no analgesia sedative, hypnotic, amnesic,muscle tone decrease, anti-epileptic; no analgesia
-zepam BDZ
-zolam BDZ
Short Acting BDZ TOMB: Triazolam Oxazepam Midazolam Brotizolam
Intermediate Acting BDZ LETAL: Lorazepam Estazolam Temazepam Alprazolam Loprazolam
Long Acting BDZ Diazepam Flurazepam Clotiazepam Nitrazepam Flunitrazepam
Which BDZ don't do Phase I metabolism? TOL: Temazepam Oxazepam Lorazepam
non-BDZ hyp Zaleplon Zolpidem Zopiclone
BDZ antagonist Flumazenil
Barbiturates and Profolol beta subunit; work without GABA; no analgesia
Barbiturates sedative-hypnotics (anesthesia) anti-epileptic sedative-hypnotics (anesthesia) anti-epileptic
thiopental sedative-hypnotic barbiturate
phenobarbital anti-epileptic barbiturate
profolol sedative hypnotic anesthesia
vigabatrin inhibits GABA transaminase, decreases GABA metabolism, increases GABA anti-epileptic anti-epileptic
Tiagabin GABA-reuptake inhibitor; increases GABA anti-epileptic anti-epileptic
Gabapentin not a GABA agonist;alpha-2 delta ligand at PQRN-Ca channel; decreases transmitter release
Baclofen GABA B agonists (presynaptic); decreases transmitter release
Endogenous Agonists GABA, endozepines
Endogenous Agonists GABA, endozepines
Endogenous Agonists GABA, endozepines
Created by: cbart004
Popular Pharmacology sets

 

 



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