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Pharm 1 unit 1
Pharm 1 - Fall 2011
| Question | Answer |
|---|---|
| frxn of drug that reaches systemic circulation? | Bioavailability (F) |
| non-ionized drugs pass faster or slower? | Faster |
| Acid labile drug | Break down in acid (don't want) |
| Metabolism: Phase 1 rxns | Oxidized or reduced to more polar form -- cytochrome P450 system |
| Phase II rxns (metabolism) | ^d polarity |
| fxrs that influence metab? | CHF (decrsd blood flow to liver), Hepatic dysfxn, ^d age |
| If not given another dose, how long does it take to rid drug from body? | ~5 half-lives |
| Steady state | Absorption = elimination (usually reached in 5 half-lives) |
| a1 receps do? | smooth-musc contrax |
| B1 receps do? | Cardiostimulation |
| B2 receps do? | Smooth-muscle relax |
| Absorp, Distribu, biotransfor/metab, elim are all? | Pharmacokinetics |
| 1+1=3? | Synergism (get more effect than expected!) |
| 1+0=2? | Potentiation (one drug is not active, but when given with another drug...increases that drug's effect) |
| Durham-Humphrey amend of 1952? | legal distinx bw nonrx and rx drugs |
| Kefauver-haris amend of 1962? | must prove safety and efficacy for the labeled indication before approval for marketing |
| pre-clin testing involve? | animal testing |
| Phases of clinical studies? | 1=test in healthy vol 2=efficacy, safety, proper dose in small group of pts with the dz 3=statis ev for safety adn effic |
| a with line over? | b4 |
| ac | before meals |
| pc | after meals |
| s with line over? | without |
| classes of controlled drugs? | 1-5 1=no accepted medical use |
| androgens stimulate? | increased sebum produx |
| comedones are composed of? | Excess sebum + sloughing of keratinocytes |
| p acnes convert sebum to FFA causing? | Inflamm response |
| vehicles for acne on oily to nl skin? | gel, soln, lotion |
| can take how long for acne meds to have effect? | 6-8 wks (may see flare initially) |
| mild acne consists of? primary tx? | open and closed non-inflamm comedones -topical retinoid |
| how can you decrs the bacterial resistance in topical abx for acne? | combine with benzoyl peroxide |
| azaleic acid | may dcrs post-inflamm hyperpigmentation in acne |
| mod acne and primary tx? | Inflamm papules and pustules w/ some non-inflamm lesions (comedones) -Retinoid + oral abx +/- BP |
| in acne, if tetracylcines and erythromycin not waorking...what is third line option? | TMP/SMX |
| OCPs can be used for mod acne in those who want BC...how long might it take to take effect? | 2-4 mo |
| with accutane...need baseline LFT, TG, CBC...then when? | 4 and 8 wks |
| when inflamm lesions are present, what therapy should be added? | antimicrobial tx |
| Which vehicle is best for hairy areas, face? | gel (soln good for hairy areas, moist folds) |
| high potency, class I steroids should only be used for how long max? | 2 wks |
| how much cream covers one adult hand? | .5 grams |
| tretinoin | retin-A |
| Benzoyl peroxide | Benzagel (topical anti bac and exfolliant) |
| Azeleic acid | Azelex, Finacea (anti bac, antiinflamm) |
| Doxycylcine | Adoxa (not for those <8..tooth discol) |
Created by:
ferrier.kath
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