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Ch,. 31 Pharm
Thyroid, antithyroid drugs
Question | Answer |
---|---|
Three hormones essential for proper regulation of metabolism in thyroid | Thyroxine (T4) Triiodothyronine (T3) Calcitonin |
Where are the three hormones located in thyroid and what are their fx | Located near the parathyroid gland which is responsible for maintaining adequate levels of calcium in the extracellular fluid |
What is hypothyroidism | Not enough thyroid hormones Primary: abnormality in the thyroid gland itself Secondary: pituitary gland is dysfunctional and not secrete TSH Tertiary: hypothalamus gland does not secrete TRH, which stimulates the release of TSH |
what is Cretinism | Hyposecretion of thyroid hormone during youth Low metabolic rate, retarded growth and sexual development, possibly mental retardation |
what is myxedema | hyposecretion of thyroid hormone during adulthood decr met rate, loss of mental/physical stamina, wt. gain, loss of hair, firm edema, yellow dullness of skin |
what is goiter | enlargement of thyroid Overstimulation by elevated TSH b/c no thyroid hormone in circulation |
common ss/sx of hypothyroidism | thickened skin, hair loss, constipation, lethargy, anorexia |
drugs for hypothyroidism | levothyroxine (Synthroid, Levothyroidl) Synthetic thyroid hormone T4 liothyronine (Cytomel) Synthetic thyroid hormone T3 liotrix (Thyrolar) Synthetic thyroid hormone T3-T4 combined Thyroid- Desiccated (dried) animal thyroid gland |
what is euthyroid | normal levels of thyroid |
what is preferred drug for hypothyroidism | levothyroxine "Euthyroid" |
what is most common side effect of thyroid drugs | cardiac dysrhythmias May cause: tachy, angina, HTN, insomnia, N/D, wt loss, sweating |
What is hyperthyroidism | excessive thyroid hormones |
What diseases can cause hyperthyroidism | Graves', Multinodular, Plummer's, thyroid storm(stress/infection and life threatening) |
What is graves' disease and what is common with it | over production of thyroid hormone and cause enlarged thyroid and exophthalmos(bulging eyes) |
what are treatments of hyperthyroidism | radioactive iodine (I131) destroys thyroid, surgery w/ hormone replacement, Antithyroid drugs: thioamide derivatives methimazole (Tapazole) propylthiouracil (PTU) |
what is adverse effect of hyperthyroidism drugs | liver/bone toxicity |
During pregnancy, what is important to know regarding hypothyroidism | Fetal growth may be retarded if maternal hypothyroidism is untreated during pregnancy Adjust dosage every 4 weeks to keep TSH at the lower end of the normal range |
When taking thyroid drugs what should nurse remind pt | take pill in morn b/c insomnia, take same time everyday and not switch brands |
When taking thyroid drugs what should nurse be cautious of | May enhance activity of anticoagulants Diabetic patients may need increased dosages of hypoglycemic meds May decrease serum digoxin levels Avoid iodine high foods (seafood, soy sauce, tofu, iodized salt) |