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ch. 48 Pharm
Antineoplastic Drugs Pt. 2
| Question | Answer |
|---|---|
| What type of drugs are CCNS-cell cyle nonspecific | Alkylating, cytotoxic antibiotics |
| How do alkylating drugs work | prevent cancer cells from reproducing alkylation |
| adverse effects of aklylating drugs | nephrotoxicity(hydration helps), peripheral neuropathy, ototoxicity |
| cytotoxic antibiotics able to treat cancer | too toxic for infections, produce BMS |
| what is unique about bleomycin | does not cause myleosuppression, but is pulmonary toxicity, pneumonitis |
| Doxorubicin adverse effects Daunarubicin | cardiomyopathy- enlarged heart turn pee red |
| Avastin, bevacizumab | blocks blood supply to growing tumor "avascular" |
| hydroxyurea (Hydrea) | treat squamous cell and some leukemias, oral only, for some, |
| imatinib (Gleevec) | chronic myeloid leukemia (CML), severe interactions "not jump for Glee" |
| mitotane (Lysodren) | "adrenal" cytotoxic drug |
| Hormonal drugs | adjuvant and palliative therapy, drug of choice |
| what if extravasation occurs | PREVENTION stop IV, not remove IV give antidote, remove IV, cover, warm/cold compresses |
| When handling antineoplatic drugs what are some care instructions | double flush |
| Two cytoprotective drugs | IV amifostine- reduce renal toxicity with cisplatin IV/PO allopurinol reduce hyperuricemia |