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ch. 48 Pharm

Antineoplastic Drugs Pt. 2

QuestionAnswer
What type of drugs are CCNS-cell cyle nonspecific Alkylating, cytotoxic antibiotics
How do alkylating drugs work prevent cancer cells from reproducing alkylation
adverse effects of aklylating drugs nephrotoxicity(hydration helps), peripheral neuropathy, ototoxicity
cytotoxic antibiotics able to treat cancer too toxic for infections, produce BMS
what is unique about bleomycin does not cause myleosuppression, but is pulmonary toxicity, pneumonitis
Doxorubicin adverse effects Daunarubicin cardiomyopathy- enlarged heart turn pee red
Avastin, bevacizumab blocks blood supply to growing tumor "avascular"
hydroxyurea (Hydrea) treat squamous cell and some leukemias, oral only, for some,
imatinib (Gleevec) chronic myeloid leukemia (CML), severe interactions "not jump for Glee"
mitotane (Lysodren) "adrenal" cytotoxic drug
Hormonal drugs adjuvant and palliative therapy, drug of choice
what if extravasation occurs PREVENTION stop IV, not remove IV give antidote, remove IV, cover, warm/cold compresses
When handling antineoplatic drugs what are some care instructions double flush
Two cytoprotective drugs IV amifostine- reduce renal toxicity with cisplatin IV/PO allopurinol reduce hyperuricemia
Created by: palmerag
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