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Phar - AntiVir

Antiviral drugs

QuestionAnswer
Acyclovir properties HSV (weak varicella, CMV) drug, blocks viral DNA Pol.
Acyclovir pharmacokinetics Oral, kidney, CSF
Ganciclovir properties CMV drug (weaker HSV drug), blocks DNA Pol.(bone marrow toxicity
Ganciclovir pharmacokinetics Poor oral, kidney, CSF
Foscarnet properties Salvage drug when acyclovir & ganciclovir don't work. Pyrophosphate analog & competitive inhibitor of viral RNA, DNA Pol. and reverse transcriptase (nephrotoxic)
Foscarnet pharmacokinetics Parenteral, kidney, CSF
Interferon properties Hep C drug, regulates Jak/Stat pathway (bone marrow depression, flu-like symptoms - nasty drug, many quit)
Interferon pharmacokinetics Parenteral
Telapravir New Hep C drug, inhibits protease
Oseltamavir (Tamiflu)properties Flu drug, neuraminidase inhibitor
Oseltamavir (Tamiflu) pharmacokinetics Oral, liver, poor CSF
Zidovudine (AZT)properties HIV drug, reverse transcriptase inhibitor (bone marrow depression)
Zidovudine (AZT) pharmacokinetics Oral, liver/kidney, CSF
Lamivudine properties HIV drug, reverse transcriptase inhibitor (selects mutation that is sensitive to AZT)
Lamivudine pharmacokinetics Oral, kidney, CSF
Efavirenz properties HIV drug, NNRTI (CNS toxicity, skin rashes)
Efavirenz pharmacokinetics Oral, liver, CSF
Ritonavir properties HIV drug, protease inhibitor, inhibits Cyp3A4
Ritonavir pharmacokinetics Oral, liver, CSF
Amprenavir (fosamprenovir) properties HIV drug, protease inhibitor (lipodystrophy)
Amprenavir (fosamprenovir) pharmacokinetics Oral, liver, CSF
Enfuvirtide properties HIV drug, entry inhibitor
Enfuvirtide pharmacokinetics Parenteral, NOT CSF
Raltegravir properties HIV drug, inhibits HIV integrase
Raltegravir pharmacokinetics Oral
Created by: bamcginty
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