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Phar - Antifungal

Antifungals

QuestionAnswer
Antifungal drugs Amphotericin B Caspofungin Fluconazole Flucytosine Itraconazole
Amphotericin B properties Amphipathic, binds ergosteral preferentially, pokes holes (nephrotoxic, fever, chills)
Amphotericin B pharmacokinetics Parenteral, NOT CSF, lasts a long time
Caspofungin properties Inhibits beta-glucan synthase, cell can't make a good barrier, exposes it to immune system (headaches, GI distress, histamine release)
Caspofungin pharmacokinetics Parenteral, liver, not really CSF
Fluconazole properties Inhibits ergosterol synthesis
Fluconazole pharmacokinetics Oral, kidney, CSF
Flucytosine properties Forms florouracin in cell, inhibits thymidylate synthetase (rarely bone marrow depression)
Flucytosine pharmacokinetics Oral, kidney, CSF
Itraconazole properties Inhibits ergosterol synthesis
Itraconazole pharmacokinetics Oral, kidney, NOT CSF
Created by: bamcginty
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