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Phar - AntiBac Prot

Bacterial protein synthesis inhibitors

QuestionAnswer
Protein synthesis inhibitors Amikacin Gentamicin Chloramphenicol Clindamycin Doxycycline Erythromycin Linezolid Quinpristine/dalfopristine
Amikacin properties Binds 30S, irreversible (nephro-oto-neuro-toxic)
Amikacin pharmacokinetics parenteral, kidney, NOT CSF
Gentamicin properties Binds 30S, irreversible (nephro-oto-neuro-toxic)
Gentamicin pharmacokinetics parenteral, kidney, NOT CSF
Chloramphenicol properties 50S, reversible (bone marrow depression)
Chloramphenicol pharmicokinetics Oral, liver, CSF
Clindamycin properties 50S, reversible (superinfection)
Clindamycin pharmacokinetics Oral, liver, variable CSF
Doxycycline properties 30S, reversible (bone, teeth problems, photosensitive)
Doxycycline pharmacokinetics Oral, liver, variable CSF
Erythromycin properties 50S, reversible (epigastric distress, cholestatic hepatitis)
Erythromycin phamacokinetics Oral, liver, variable CSF
Linexolid properties 50S, reversible (thrombocytopenia)
Linexolid pharmacokinetics Oral, usually IV, liver, CSF
Quinupristin/dalfopristin properties 50S, reversible (venous inflammation, arthralgia)
Quinupristin/dalfopristin pharmacikinetics Parenteral, liver not CSF
Created by: bamcginty
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