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Pharm Unit III

QuestionAnswer
PAE? PCNs,Cephs,Clarythromycin and Erythromycin
PAE critical # and parameter? Time>MIC >40% of the dosing interval or day
CDKR? FQs, AGs, Azithromycin
CDKR critical# and parameter? AUC/MIC >25, 100 ideal
DOC for strep pharyngitis if PCN allergy? Erythromycin
DOC for atypical pneumonia pathogens? Macrolides and FQs
DOC for meningitis? Ceftriaxone + Vanco
Main uses of natl PCNS? Syphilis,strep pharyngitis, meningitis
B-lactamase producing orgs? Staph,H.flu,M.cat, E.coli,Klebsiella
Spectrum of A of 1st gen cephs? Staph,Strep,EKP
MOA of FQs? Inhib DNA gyrase &topisomerase IV = rapid and lethal cessation of DNA replication
Drugs that can elongate QT? Moxy & Eryth
Interax w/warfarin to ^INR? Bactrim,Metronidazole, Clarithromycin,Erythromycin, FQs (C&L)
Interax w/Theophylline? Clarithro,Erythro, Cipro
MOR of FQs? Gene mut,Efflux pump, altered permeability
Used to treat entc? Gentamicin+Ampicillin 2nd:Gentamicin+Vanco
Few uses for FQs? UTI (if E.coli resis to Bactrim), CAP, Osteomyelitis d/t G-pathogens
Created by: ferrier.kath
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