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AE's Pharm III

Adverse Effects

QuestionAnswer
AE's Penicillins Generally WT, Diarrhea, Rash, Seizures in HIGH doses, neutropenia/thrombocytopenia
Drugs that don't need rnal adjustment Clindamycin, Ceftriaxone, Azithro/erythro, Nafcillin, Doxy/minocycline
Drugs cause False + fever B. lactams, PCN's, Cephs, Salcylates, Phenotoin
AE's Cephalosporins Generally WT, 5-10% cross w/PCN's Diarrhea, Neutropenia, thrombocytopenia, platelet dysfxn
AE's Carbapenems Seizures, rash, anaphlaxis, cross w/ B-lactams
Gram - specialist Monobactams, Aminoglycosides
AE's Monobactams Rash, N/V/D rare cross-sensitivity to PCNs and ceps
Tx options w/ monobactams G- Sepsis, pneumonia, osteomylitis, UTI's
AE's Vancomycin Red man syndrome, oto and nephrotoxcity
Monitoring for Vanco trough levels, high doses: oto and nephrotoxicity
AE's for FQ's limited <18yo and pregnant women: Bone/Joint/cartilage erosion GI: MC, CNS: dizziness, lightheadness HA insomnia
AE's For TMP/SMX 15% sulfa allergy, GI, Rare life-thretning: Steven-johnson's, blood dyscrasias, hepatotoxic rxns & hyperkalemia
CI TMP/SMX Hypersensitivity, folate deficiency anemia, infants <2m, marked hepatic or renal dysfx, bf
AE's Aminoglycosides Oto tox, Neprhrotoxicity
AE's Tetracyclines Teeth and bone discoloration CI <8yo or pregnancy, GI upset, photosensitivity
AE's Macrolides: Erythro and Claritrho GI: N/V/D/ abd cramps Rare: hearing loss, Vtach, QT prolongation
AE's Clindamycine Diarrhea 20% Pseudomembranous colitis
AE's Metronidazole Nerological effects: seizures at high doses, Disulfiram like effect, GI upset, metallic taste, darkened urine
Created by: becker15
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