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jeopardy for pharm
| Question | Answer |
|---|---|
| two ex anti-staph pcn | nafcillin, dicloxacillin |
| common meningitis pathogens | s. pneumonia, nisseria meningitis, h. flu |
| DOC for n. gonorrhea | ceftriaxone (IM) |
| used w/gentamicin to treat enterococcus | ampicillin |
| common sinusitis pathogen | s.pnemo, h flu, m. cat, fungus |
| common osteomyelitis pathogen | staph aureus, staph epidermitis |
| usual dosing for PO azithromycin | 500mg day 1, 250 mg x4day PO |
| type of susceptibility testing | e test, kirby bauer, macro/micro dilution |
| DOC for early lyme dz | doxy |
| BLI combined w/ampicillin | sulbactam (iv) |
| common AECB pathogens | H flu, M cat, S pneumo, viral |
| DOC for PCP | TMP/SMX |
| recommended for COPD exacerbation if FEV1<50% | oral burst prednisone |
| abx require pharmacokinetic monitoring | vanco, AG |
| common UTI pathogens | Klebsiella, E coli, Enterococcus, Proteus |
| DOC for HCA-MRSA | Vanco |
| FQ gen w/best G+ coverage | 4th gen |
| DOC for C. difficile | Metronidazole |
| DOC for Mycoplasma Pneumonia | Erythromycin |
| FQ gen w/ best G- coverage | 2nd gen |
| Mechanism of interaction w/antacids and iron salts | chelation therefore decreased absorption |
| antipseudomonal PCN combined with tazobactam | piperacillin |
| Macrolide MOA | inhibit protein synthesis |
| common cervicitis/urethritis/proctitis pathogens | gonorrhea and chlamydia |
| FQ for pseudomonas infections | Cipro |
| recommended for pt w/mild COPD | SABA or Anticholinergic, smoking cessation, Flu shot |
| PCN for AOM resistant to amoxicilling | Augmentin |
| Common AOM pathogens | s pneumo, h flu, m cat |
| ONLY COPD Tx that slows dz progression | smoking cessation |
| common appendicitis pathogens | KEEPS, Klebsiella, Ecoli, enterococcus, Pseudomonas, Staph |
| DOC for strep pharyngitis | Pen-K |
| macrolide w/highest F | Clarythromycin |
| 3 abx classes active against intracellular pathogen | FQ, Macrolides, tetracyclines |
| bacteria in which vanco resistance is seen | Enterococcus (complete), Staph Aureus (intermediate) |
| recommended for pt w/moderate COPD | SABA or anticholinergic, and scheduled LABroncho dilator and flu shot and smoking cessation |
| improve survival if used >16hrs/day | O2 therapy |
| inhibition of bacterial DNA gyrase | FQ |
| enzymes that inactivate PCN and cephs | b-lactamase |
| strep mechanism of PCN resistance | altered PBP sites |
| main feature of AG spectrum of activity | Gram - aerobes |
| macrolide w/most significant drug interactions | erythromycin |
| interacts w/ TMP/SMx to sig increase INR | warfarin |
| used to treat trichomoniasis | metronidazole |
| common AE of oral erythromycin | N/V/D abd cramps |
| first line treatment options for smoking cessation | behavior therapy, NRT, bupropion, varencline |
| 3 respiratory FQ | moxifloxacin, levofloxacin, gemafloxacin (S. pneumo coverage) |
| options for H. pylori Rx | Amoxicillin, tetracycline, metronidazole |
| macrolide w/longest 1/2 life | azythromycin |
| DOC for syphillis | PCN |
| relative activity of Ceph generations vs. gram - bact | 3rd gen - most coverage, 2nd - next most coverage, 1st gen - worst coverage |
| so called 4th generation ceph | Ceftaroline, Cefipime |
| caused by legionella, chlamydia, mycoplasma | CAP |
| simplified 1st gen spectrum of activity for cephs | staph, strep, EKP |
| asthma - prevents inflammation but doesn't treat it | leukotriene modifiers |
| typical pneumonia pathogen harmful for HIV patients | pneumocystitis jirovecii |
| biomarker appears to be specific to bact infections and reflect infection severity | PCT-procalcitonin |
| prevent w/judicious use of ABX | abx resistance |
| cephs - 3rd gen ceph with good antipseudomonal activity | Cephtazidime (fortaz) |
| DOC for atypical pneumonia | Macrolides (DOC) - Erythromycin, Clarithromycin, Azithromycin, Doxy, Moxifloxacin |
| may cause ototoxicity and nephrotoxicity | AG and Vanco (must do pharmacokinetic monitoring) |
| ceph with activity against MRSA | Ceftaroline |
| caused by C. Diff | pseudomembranous colitis |
| used for asthma Sx at night or w/prolonged exercise | LAB2agonist |
| LRT infx - hemodynamically stable, improving clinically, able to ingest meds, functioning GI tract | criteria from switching from IV antibiotic tx to oral |
| AG for psudomonas | tobramycin |
| 2 2nd gen anti-anaerobic cephs | cefotetan and cefoxitin |
| disease caused by Rickettsia | rocky mountain spotted fever |
| tx for acute exacerbation of asthma w/decreased response to SAB2agonist | PO steroid burst (prednisone burst) |
| abx w/good anaerobe & parasite coverage | metronidazole |
| criteria for abx use for AECB | need 2 of the following, Increased sputum volume, increased sputum purulence, Increased dyspnea |
| may cause CNS stimulation, Gi distress, tendon inflammation, or QT prolongation | FQ |
| abx w/good anaerobic and gram + coverage | Clindamycin |
| red man syndrome w/rapid diffusion | vanco |
| indicated for prophylaxis or treatment of influenza A&B | Oseltamivir, Zanamivir |
| Tx of choice for gonococcal cervicitis | Ceftriaxone, 250 mg x 1IM + Zithromax or doxy |
| most likely to cause seizures | Carbapenems, specifically imipenem (PCN w/High doses) |
| borrelia burgdorferi causes this | Lyme dz |
| therapy of choice for B. pertussis | Erythromycin |
| Asthma - thrush, coughing, dysphonia | AE of ICS (prevent with rinse n spit) |
| abx w/no significant absorption when given PO | vanco |
| 5-10% x-sensitiity w/PCNS | cephs (don't use in someone w/TYPE 1 PCN allergy) |
| recommended for CAP in previously healthy outpts w/no recent Abx | macrolide or doxy |
| Essential tx for PERSISTENT asthma | ICS |
| cause disulfiram rxn w/concominant EtOH | metronidazole |
| DOC for uncomplicated UTIs | TMP/SMPx as long as E.coli resistance isn't >20% |
| caused by Treponema pallidum | syphillis |
| agent used to treat chlamydia | doxy or zithromax |
| can cause tooth discoloration in young children | tetracyclines |
| MC infectious cause of death in US | CAP |
| measure of how sensitive an organism is to abx tested | minimum inhibitory concentration MIC |
| DOC for AOM | Amoxicillin |
| primary pathology of asthma | inflammation |
| caused by bordatella pertussis | whooping cough |
| classic indications of bact infection | fever, elevated WBC w/left shift in neutrophils, procalcitonin |
| abx combined with sulfamethoxazole | trimethprim |
| lrt infx- abx recommended for acute bronchitis | NONE - chicken soup, rest |
| CAP mechanisms of infection | 1. inhalation aerosolized particles 2. seeding via bloodstream from extra-pulmonary infection 3. aspiration of oropharyngeal contents |
| intracellular pathogens | chlamydia, ureaplasma, legionela, mycoplasma, neisseria |
Created by:
ashleylafontaine
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