Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Pharm Abx 2
Fall 2011, pharm I
| Question | Answer |
|---|---|
| What is the name of the main sulfa abx used? | Trimethoprim/Sulfamethoxazole (TMP/SMX) |
| MOA of TMP/SMX? | -Blocks folate pathway=inhib DNA, RNA, protein produx |
| TMP/SMX is the DOC for what? | -Pneumocystitis pneumonia (AIDS) (for trtmt and prophylaxis) -UTI:uncomplicated cystitis (when E.coli sensitive) |
| Other common uses of TMP/SMX? | -RTI, UTI, GI infex |
| TMP/SMS comes in what forms? | Oral, IV |
| TMP/SMX trade names? | Bactrim, Septa |
| AE of TMP/SMX? | -HyperK+ (esp w/ACEi/ARB, K+sp diuretic, K+supp) -15%sulfa allergy -GI upset, rash, photosens -Rare: TENS/SJS, leukopenia.. |
| CI for TMP/SMX? | -Hypersens to any sulfa drug, folate defic anemia, infants<2mo, marked hep/renal dysfxn, lactat |
| What is a special drug interax to consider w/TMP/SMX? | -Warfarin..should decrs dose (CYP2C9 inhib) |
| Gentamicin and Tobramycin are both examples of? | Aminoglycosides |
| Aminoglycoside spectrum of activity? | -Good activity against all G- aerobes |
| What are aminoglycosides used for, commonly? | -Serious hosp-acquired infex caused by enterobacteriacea, pseudomonas |
| Common AEs of aminoglycosides? | Ototoxicity - usually irreversible |
| Common example of a tetracycline? | Doxycycline |
| Trade name of Doxycycline? | Doxy,Vibramycin |
| Resistance to tetracyclines is wide-spread, what may be the cause? | Included in animal feeds to promote wt gain |
| What is the spectrum of activity in tetracyclines? | Broad |
| Any pharmacokin consid w/ tetracyclines? | -Absorption is decrsd by milk, antacids, iron supps, other Ca2+, alum, iron |
| Doxycycline is DOC for? | Early stage Lyme dz |
| Dosing for Doxy? | 100mg bid x 7-10days |
| AEs of tetracyclines? | -Teeth discolor in kids<8 and preg/lactat, GI upset, photosens |
| What are the Macrolide meds? | -Erythromycin -Clarithromycin -Azithromycin |
| Trade name of Azithromycin? | Zithromax |
| Erythromycin covers? | Atypical RTI pathogens |
| How is Erythromycin elim? | Excreted in bile |
| What is the DOC for Bordatella pertussis? | (whooping cough) -Erythromycin |
| Erythromycin inhibits metab of? | -Theophylline and warfarin (=^d levels) |
| If a drug has a ^er bioavail, what does that mean for the GI tract? | Less effects! Erythromycin 25% vs Clarithromycin 50%! |
| Clarithromycin inhibits metab of? | -Theophylline and Warfarin =^d levels, but only 50% amt that Erythromycin affects it |
| Clarithrymycin advantages over Erythromycin? | -^spectrum of activity -Less drug interax -Fewer GI side effects |
| Azithromycin has great action on which class of dz's? | STIs |
| Which macrolide really gets into the cells and has a t1/2 of 68hrs? | Azithromycin |
Created by:
572680793
Popular Pharmacology sets