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Cocaine

PSY 315

QuestionAnswer
TYPES OF ADMINISTRATION IV (short) Smoking Chewing (coco leaf) SC (local anethetic) IN (snort)
Absorption Oral : poor, long Smoke : quickest, secounds IV : quick, minutes
Distribution goes through circulation ebfore hitting the brain
Metabolism in blood and liver
excretion urine and kindney
mechanism of action block reuptake of DA, NE, & 5HT in the VTA, NA & thalmus & brainstem
Pharmocological effects * Sympathetic Response (NE) * local anethetic * decrease vagus nerve stimulation (HR) with low dose * increases BP and vasocontriction with moderate/high dose. *stimulates respitory centers * Pryrogenic effect *causes anxiety, fatigue, a
Clinical applications *local anethtic *dentist (novacaine)
side effects *CNS effects similar to that of amphetamines *kindling- during chronic use, sensitivity develops allowing a small dose to become toxic *nasal membrain damage *crack babies
crack smoking the free form of acid stable cocaine
free-basing basie freed from cocaine hydrocholide by dh20 or baking soda
coca botanical orgin of cocaine
parasitosis feeling of bugs crawling on skin
crack babies children exposed to cocain ebfore birth (easilt crosses placental barrier)
ICE smokable methamphetamine
ephedrine derived from a plant, cause NE release
CAT a designer drug similar to methamphetamine (methcathirimane)
Created by: pgalbato
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