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Res. Pharm. Ch.6

Respiratory Pharmacology

QuestionAnswer
THE ACTION OF THESE DRUGS IS MEDIATED BY__________ADRENERGIC RECEPTORS. B2.
STIMULATION OF THESE RECEPTORS RESULT IN (BRONCHODILATION;AIRWAY SMOOTH MUSCLE RELAXATION). BETA 2
THE MOLECULAR STRUCTURE OF CATACHOLAMINES: BEZINE RING,TWO HYDROXYL GROUPS,AMINE SIDE CHAIN.
THREE NATURALLY PRODUCED CATACHOLAMINES: EPINEPHRINE,NOREPINEPHRINE, AND DOPAMINE.
REGARDING MOLECULAR STRUCTURE,HOW ARE EPI. AND RAC. EPI SIMULAR? AND HOW ARE THE DIFFERENT? THEY ARE MIRROR IMAGES,RACEMIC EPI. HAS LESS CARDIAC SIDE EFFECTS.
WHAT IS RACEMIC EPI. USED FOR IN REGARDS TO UPPER AIRWAY OBSTRUCTION? TREATS INFLAMMATION.
WHAT IS ISOPROTERENOL? A SYNTHETIC CATACHOLIMINE,BETA 1 & BETA 2, USED TO TREAT SLOW HEART RATE.
WHAT IS COMT,WHERE IS IT FOUND,AND WHAT IS THE ROLE IN CATACHOLIMINES? COMT IS FOUND INSIDE THE CELL,THIS IS WHERE THE BREAKDOWN OF CATACHOLIMINES WILL TAKE PLACE.
WHAY ARE THE EFFECTS OF CATACHOLIMINE BRONCHODIALATORS LIMITED TO A FEW HOURS? COMT WILL DESTROY IT RAPIDLY.
WHAT CATACHOLIMINES WERE HISTORICALLY USED AS NEBULIZED BRONCHODIALATORS? ISOPROTERNOL
WHAT EFFECT DOES LIGHT HAVE ON CATACHOLIMINES? IT WILL DESTROY IT WITH TIME; MOST IMPORTANTLY IT WILL CHANGE IN COLOR.(PINK).
WHAT ARE THE TWO ADRENERGIC BRONCHODIALATOR DRUGS DISCUSSED IN THE CHAPTER THAT HAVE TE RESORCINOL NUCLEUS IN THEIR MOLECULAR MAKEUP? METAPROTENEROL AND TERBUTALINE.
METAPROTENEROL ALUPENT- SVN,MDI (2~3 PUFFS),TAB,AND SYRUP. DURATION~(2-6HRS).
ALBUTEROL PROVENIL,VENTALIN-SVN~2.5MG DOSE,MDI~(2 PUFFS TID),TAB,AND SYRUP.ONSET~15 MIN.
LEVALBUTEROL XOPENEX- SVN AND MDI
SALMETEROL SERAVENT-(BID),DPI
FORMOTEROL FORADIL- DPI,(BID),30-60MIN
ARFORMOTEROL BROVANA-(BID) 30-60MIN
INDACTEROL ARCAPTA-DPI (24HRS)
______________IS BETA 2 ADRENERGIC THAT MAY BE GIVEN IV TO A PATIENT WITH EMERGENT BRONCHOSPASM. TERBUTALINE.
THE MAJOR BETA 2 DRUG WITH SALIGENIN NUCLEUS IS: ALBUTEROL.
WHAT IS FEV1? IT DETERMINES IF THERE IS AN AIRWAY OBSTRUCTION.
THREE DEVICES USED VIA- INHALATION ROUTE: DPI,MDI,SVN.
Created by: Stefgarner