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ACh antagonists
info about direct and indirect acting anatagonists of ACh
| Question | Answer |
|---|---|
| Atropine - Administration, MOA, Clinical Use and CI | Oral, parenteral, inhaled, ophthalmic, Competitive inhibitor at postgang M receptor. Used in eye exams, cholinergic poisoning. low dose causes bradycardia; high dose bks M receptors on muscle, causing tachycardia. Very high dose cause coma (toxic) |
| Homoatroptine | topical admin to eye; bks responses of eye muscles to cholinergic stimulation; used as ophthalmic mydriatic agent (pupil dilation), to diagnose glaucoma |
| Scopolamine | admin: oral, intramuscular, subcutaneous; used to treat motion sickness |
| cyclopentaolate | topical admin, dilate pupil |
| tropicamide | topical admin, dilate pupil |
| ipratropium | aerosol, ACh antagonist that causes decreased contractility of smooth muscle. bronchodilator in COPD |
| tiotropium | aerosol; ACh antag at M receptors. maintenance treatment of COPD. |
| benztropine | oral and parenteral admin. Ach antagonist at M receptors, decreases tremor and rigidity. Log DOA. Tx parkinsons |
| Dicyclomine | Oral, intramuscular. Antag at M receptors. Exerts nonspecific spasmolytic action on sm muscle of GIT. Tx peptic dz, hypermotility diarrhea. |
| trihexyphenidyl | oral. tx parkinsons. small doses causes CNS depression and large doses causes CNS stimulation |
| oxybutynin | oral and transdermal admin. bladder muscle relaxant, suppresses urge to void. inhib detrusor muscle. topical can cause itch and redness; ase: dry mouth, GI effects |
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