click below
click below
Normal Size Small Size show me how
PICO & Evidence Lvls
PICO & Levels of Evidence Information
Question | Answer |
---|---|
Systematic Reviews of Randomized Control Test (Study) | Has internal controls, comparing many studies |
Individual Randomized Control Test (Study) | Has internal controls, one study |
SR & Individual RCT’s Cohort Study | Has bigger group; more generalized. May apply to your pt. |
Outcome Study | Has a lot of people with specific outcome. Control people, measurement |
SR of Case Control | Compares many studies of general information |
Individual Case Study (clinical) | Gives value to the individual but not to majority population |
Case Series | More control but not a lot |
Expert Opinion | Value but limitations |
Inclusion criteria | Anything the pt had that allowed them to be included in the group |
Exclusion criteria | Anything someone in the inclusion group has that excludes them from the study |
Subject reimbursement | Payment from participating in the study |
Signing waivers | Pt signs so they are aware they are in a trial |
Blinding | Can’t know any details, no Tx ,recording, or recipient bias |
Recorder reliability | (Repeating measures) giving testers practice and training before the study |
Research approval | From powers that be |
Randomization | Different levels of dividing the group up so that it is random |
Statistically sound study | Must have 30 or more people in it |
Intention to treat (ITT) | Report the reason that any person dropped out of the trail (Proof that it wasn’t the treatment that caused the person to drop out or die before the trial ended) |
Confounding variables (CV) | Factors that could make the study better or worse; Can’t control everything |
Name some confounding variables | Ex. Hip replacement, Atrophy, Time of Day ** very important for stretching**, Current or past activities, Diet/meds, Arthritis, Socioeconomics, Male/female, Ages, Co-morbidities; steoporosis, diabetes, Diseases, Cooperation of patient, Family influences |
Foreground Question (4 components): | P – Patient (everything) problem (everything) population I – Intervention (what was studied) C – Comparison (treatment or placebo) O – Outcome (SPECIFIC!!!) Return to work |
PICO Example: | P- 55ylo, female, hemo stroke I- Retro Gait C- Standard rehab vs standard rehab + retro gait O- Increase gait skills; decrease assistance and decrease assisted device in 3 weeks |
Places to look for Journal info: | ProQuest & medline – web sites; CINAHL – Journal directory; Cochran Database – only SR (compare pt with MANY studies); APTA – has all available for free if you are a member |
External Validity | The truth of information gathered matches the patient you are treating (actual clinical practice) |
Internal Controls | Things that make a study more valid; -If confounding variables are too great, we can use the study with conditions (monitor more often) - if not doing treatment, come up with what treatment you will do instead - how effects outcome |
Evidence Based Practice (EBP) | Clinical expertise w/patient's values & best research available. Patient always decides what the best option for them is once given the choices. |
List the levels of evidence: | 1. SR of Randomized Control Test (Study); 2. Individual Randomized Control Test (Study); 3. SR & Individual RCT’s Cohort Study; 4. Outcome Study 5. SR of Case Control; 6. Individual Case Study (clinical); 7. Case Series; 8. Expert Opinion |
List the internal controls: | 1. Inclusion criteria; 2. Exclusion criteria; 3. Subject reimbursement; 4. Blinding; 5. Research approval; 6. Randomization |
What is another name for Foreground Question (4 components)? | PICO |
Ideally, these people should always be” blinded” | 1. Patients 2. Treating Clinicians 3. Data Collectors 4. Data Analysts |
1. Patients 2. Treating Clinicians 3. Data Collectors 4. Data Analysts Should be blinded in all SR & RCT's? | Yes, but **Not usually possible in PT** |
True or False - If ITT is not done it can cast doubt on the study | True, if ITT is not done it can cast doubt on the study |
How do you translate the evidence into practice? | 1. Generate evidence from research 2. Synthesize evidence 3. Develop evidence based clinical policies 4. Apply the policies |
For EBP, what your given: patient circumstances, patient value, and the evidence...whats your best option? | Where they overlap is the best option (1. Patient circumstance 2. Patient values 3. Evidence) |
Evidence Based Practice (EBP) | Integration of clinical expertise w/ the pt values & the best available research evidence to ensure optimal outcomes |
Goal of EBP | Improve clinical performance through critical evaluation of the current evidence |
In randomization, name some extraneous variables | Patient, age, race, gender, symptom duration, condition severity, comorbidities, intellectual status, motivation, & treatment expectations. |
How can you avoid bias from the investigators in allocating to groups? | Do in this order: informed consent, enroll in trial, sealed envelope from locked file cabinet to reveal group assignment |
True or False - It may still be possible to use the patient data set using an ITT approach | True, It may still be possible to use the patient data set using an ITT approach |
Validity of Systematic Reviews | We must distinguish SR’s from unsystematic “literature reviews” where the authors survey published literature w/o explicit search or selection criteria |
4 key validity issues of SR | -Address PICO,explicit/sufficiently narrow in scope -Search for relevant studies should be detailed, exhaustive & fully revealed -Use/report explicit criteria for assessing methodologic quality -Adequate reliability btwn 2 or more assessors should be told |
What does PICO stand for? | Patient, Intervention, Comparison, and Outcome |
Background questions are developed to? | Enhance knowledge relative to a specific disorder |
Reliability (intra- and inter- tester) | The extent to which an experiment, test or measuring procedure yields the same results on repeated trials |
What is the difference between intra- and inter- tester | Intra - one person doing testing, 7%. Inter - two people doing testing, 15%. |
Difference between internal & external validity | Internal validity - Benefit of the Tester & External validity - can NOT control |
Identify 3 considerations of the patient and research in order to make clinical application judgement | 1. Patient circumstance 2. Patient values 3. Evidence |