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muscloskeletal 68q
extra 68Q
| Question | Answer |
|---|---|
| MOA: Inhibits bone resorption SE: Patients may experience localized skin reaction to the injection or systemic reaction if allergic to salmon | Calcitonin - Miacalcin Nasal Spray, Fortical Nasal Spray |
| MOA: Provides calcium for bone formation U: treats post menopausal osteoporosis and prevention of progressive bone loss | Calcium Carbonate - Oscal |
| SE: Hot flashes Peripheral edema leg cramps/muscle spasm | Raloxifene - Evista |
| DI: Take with food or milk Avoid aspirin May cause drowsiness Do not drink alcohol SE: G.I. Upset | All NSAIDS |
| Use: Anti-inflammatory, Analgesic, 1st line for gouty arthritis | Indomethacin - Indocin |
| Use: Anti-Inflammatory & Analgesic ~also marketed as immediate release Potassium Salt (Cataflam) | Diclofenac - Voltaren |
| Uses: Osteoarthritis, Rheumatoid arthritis and Juvenile Rheumatoid arthritis | Meloxicam - Mobic |
| Considered a Schedule III-V drug Commanders will consider it a locally controlled item | Fiorinal |
| Considered a Schedule III-V drug | Isometheptene Mucate, Dichloralphenazone, Acetaminophen - Midrin |
| Intoxication or poisoning due to an overdose or excessive use of the ergot alkaloids is known as ........... | Ergotism |
| Use: Abort or prevent vascular headaches (migraines) Controls effectively up to 70% of acute migraine attacks *contraindicated in pregnancy* SE: Vertigo, itching, nausea and vomiting | Ergotamine Tartrate - Ergomar |
| Migranal is a ____________ DHE45 is a ______________ | nasal preparation injectable |
| A new class of anti-migraine agents that work primarily on the serotonin receptor causing cerebral vasoconstriction | Triptans |
| MOA: Reduces the production of uric acid | Allopurinol - Zyloprim, Aloprim |
| MOA: Increases urinary excretion of uric acid | Probenecid - Benemid |
| What does DMARD stand for? | Disease Modifying Anti-Rheumatic Drug |
| Agents that completely block nerve impulses to skeletal muscles causing complete skeletal muscle relaxation | Neuromuscular Blocking Agents |
| Agents cause complete blocking of nerve impulses so most pharmacists do not strictly consider them skeletal muscle relaxants | Neuromuscular Blocking Agents |
| When nerve impulses that stimulate skeletal muslce tone become blocked at the spinal cord and results in diminished skeletal muscle tone | Skeletal Muscle Relaxation |
| Three major categories of skeletal muscle relaxants | Neuromuscular Block Agents Centrally Acting Agents Direct Acting Agents |
| The onset of blockade is usually rapid as motor weakness gives way to | total flaccid paralysis |
| What 2 drugs are short acting NMBs with an onset of ~1 minute and a duration of action less than 30 minutes? | Mivacurium - Mivacron Rapacuronium - Raplon |
| An acetylcholinesterase inhibitor used to antagonize or reverse the action of these agents | Neostigmine - Prostigmin |
| MOA: acts like an excess of acetylcholine at NM junction to depolarize the muscle receptor site and prevent its repolarization-causes an initial muscle contraction | Depolarizing blocking agents |
| Use: ultra-short acting neuromuscular blocking agent used as an adjunct to anesthesia or for rapid sequence intubation (short procedures Is the only depolarizing agent approved for use in the U.S. | Succinylcholine - Anectine, Quelicin |
| Use: Muscle spasticity and rigidity associated with multiple sclerosis or cerebral palsy, also spinal cord injuries SE: Frequent urination | Baclofen - Lioresal |
| MOA: Reduces skeletal muscle tone through a direct effect on contraction. | Direct Acting Skeletal Muscle Relaxants |
| Uses: Treatment of malignant hyperthermia | Dantrolene - Dantrium |
| Uses: Analgesic: drug of choice for myocardial infarction, severe pain from terminal cancer, and pain associated with pulmonary edema | Morphine - MS Contin, Oramorph, Roxanol, Duramorph |
| Uses: Antitussive and Analgesic | Codeine |
| Uses: Maintenance treatment of narcotic addiction | Methadone - Dolophine |
| Uses: Mirgraine headache | Stadol |
| Primary military use DI: Take with food to minimize GI upset | Naltrexone - Revia |
| Use: chronic alcoholism SE: garlic or metallic like taste DI: avoid alcohol and alcohol containing products | Disulfiram - Antabuse |
| Cautions: Head Injury-increase intracranial pressure Asthma-possible respiratory depression Combination with other CNS depressants-potentiation | Use of Narcotics |
| Comes in many combinations Scheduled drug | Codeine with Acetaminophen - Tylenol #3 |
| General Properties: Analgesia Antitussive Mood Alteration Gastronintestinal Effects | Narcotic Analgesics |
| MOA: Interneuronal blocking agents, their limited efficacy (effects) may be due solely to general depression of the CNS SE: CNS Depression (drowsiness) Dizziness | Centrally Acting Skeletal Muscle Relaxants |