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Antiviral
ch 40 Pharm
| Question | Answer |
|---|---|
| What immunocompromised px can be infected? | Cancer: leukemia, lymphoma transplant pxts AIDS paxts |
| What viruses can be controlled by antiviral therapy ? | CMV, herpes, hepatitis, HIV, flu, RSV |
| Can you completely get rid of a virus? | No, you only suppress or slow the replication and growth |
| What are some opportunistic infections? | protozoal: Toxoplasmosis fungal: thrush viral: herpes, CMV |
| What is the difference b/n antiviral and antiretroviral drugs? | antiviral is for anything other than HIV antiretroviral is for HIV infections |
| What are some viruses treated by antiviral drugs | HSV 1 oral, HSV 2 genital herpes, VZV chix pox, shingles, Kaposi's |
| What are nonretroviral drugs for Flu A? | amantadine (symmetrel) rimantadine (Flumadine) |
| Why would you pick rimantadine over amantadine? | rimantadine has less CNS adverse effects, less GI upset |
| What common antiviral drug treats herpes? | acyclovir (Zovirax) "so fire ax" - burns |
| What antiviral drug treats CMV retinitis? | ganciclovir (Cytovene) "sight" |
| What are adverse affects of ganciclovir? | dose limiting toxicities - bone marrow toxicity |
| What causes renal toxicity? | foscarnet and cidofovir |
| What antiviral drugs fight flu A & B? | oseltamivir(Tamiflu) & sanamivir (Relenza) |
| What are the adverse effects of Tamiflu? | vomiting and nausea |
| What are the adverse effects of Relenza | diarrhea, nausea and sinusitis |
| How soon should you take Tamiflu and Relenza at onset of flu symptoms? | Within 2 days |
| What is the test for AIDS? | ELISA - detects antibodies of virus in blood |
| How is AIDS transmitted | sex, needles, mother to baby |
| What is HAART? | highly active antiretroviral therapy "cocktail" |
| What is the first antiretroviral drug? | zidovudine (Retrovir) known as AZT |
| Which antiretroviral drug can be given to pregnant women? | zidovudine(Retrovir) |
| What are the adverse effects of zidovudine(Retrovir)? | bone marrow suppression |
| What fusion antiretroviral drug is in a new class? | enfuvirtide(Fuzeon) |
| What should a nurse asses with antiviral and antiretroviral therapy? | underlying disease, med hx, allergies, baseline vitals, nutrition, drug interactions |
| What teaching can be done with antiviral and antiretroviral therapy? | proper application technique, hand washing, finger cot, consult doc before taking meds, good hygiene |