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Antibiotics Pt. 2

Ch 39 Pharm

QuestionAnswer
How much is a microgram? How much is a milligram? One millionth of a gram One thousandth of a gram
What is MIC Minimum inhibitory concentration, the least amount of drug to be effective to kill bacteria
What is synergistic effect? two anticiotics given together is greater than individual
What is VRE? What is MRSA Vancomyocin resistant Enterocuccus Methicillin resistant staph a. both multi drug resistant
Feature of Aminoglycosides cidal, prevent protein synthesis, have postantibiotic effect, most IV,lots of H2O MEAN side effects: nephro/ototoxicity
What are the three most common Aminoglycosides? amikacin, gentamicin, tobramycin (mycin)
Which Aminoglycoside can be given orally? Neomycin
What is concentration dependent killing? levels above the MIC, usually once a day dose, peak/trough levels measure to see renal clearance
What do Aminoglycosides treat? serious G- infections: Pseudomonas, E coli, Proteus, Klebsiella, Serratia Used in combo
Quinolones/Fluoroquinolones Fluoroquiniolones, oral, cidal, "Quinn has flourescent locks", alter DNA, no Ca, mg, zinc,copper
Name some Quinolones norfloxacin, ciprofloxin, levofloxacin,noxifloxacin
What do Quinolones treat? Anthrax, UTI's, resp, skin, bone, joint, STD's
Quinolone adverse effects Prolong QT interval rupture tendons/ tendonitis
Clindomycin(Cleocin) bone infections, intraabdominal, cause pseudo colitis
linezolid(Zyvox) VRE/MRSA; no wine, aged cheese
metronidazole(Flagyl) anaerobic
Nitrofuantoin(Macrodantin) UTI's
Quinupristin/dalfopristin VRE/MRSA, IV only,
vancomycin cidal,MRSA, IV better Effects: red man syndrome,
symptoms of nephrotoxicity symptoms of ototoxicity urinary casts, proteinuria, incr. BUN/creatinine levels - dizziness, tinnitus, hearing loss
symptoms of ototoxicity
Created by: palmerag
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