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Pharmacology Ch 7
Pharmacology
| Question | Answer |
|---|---|
| Adverse Drug Reaction | Any noxious, unintended, & undesired effect that occurs at NORMAL drug doses - those taking multiple drugs, the very young & very old are at increased risk |
| Side Effect | A nearly unavoidable secondary drug effect produced at therapeutic doses |
| Toxicity | Adverse drug reaction caused by excessive dosing (sometimes may occur at normal dosing - neutropenia from anti-CA drugs) |
| Allergic Reaction | Immune response - determined mostly by the degree of sensitization of the immune system - very few drugs cause this |
| Idiosyncratic Effect | Uncommon drug response d/t genetic predisposition (ex. succinylcholine-induced paralysis) |
| Iatrogenic Disease | Drug- or physician-induced disease - essentially identical to naturally occurring pathology (dopamine -> schizophrenia) |
| Physical Dependence | Develops during long-term use of certain drugs - body has adapted to the point that abstinence syndrome would occur if use is discontinued |
| Carcinogenic Effect | Causes cancer |
| Teratogenic Effect | Causes birth-defects |
| Hepatotoxic Drugs | Leading cause of liver failure in US - don't combine hepatotoxic drugs |
| QT Interval Drugs | Prolong QT interval - risk of torsades de pointes, a dysrhythmia that can progress to fatal V-fib |
| Medication Errors | Any preventable event that -> inappropriate medication use or patient harm. |
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