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nAChR Blockers

Fundamentals II

QuestionAnswer
Tubocurarine autonomic ganglia blockade, release histamine, long duration but no longer available
Metocurine Moderate histamine release, long duration but no longer available
Pancuronium moderate cardiac mAChR block, kidney deacteylation, widely used in surgery w/intermediate duration
Pipecuronium kidney deacetylation, very long duration
Doxacurium very long duration
vecuronium kidney & liver deacetylation, widely used in surgery, intermediate duration and no side effects
Atracurium minor histamine release, spontaneous hydrolysis, widely used in surgery, intermediate duration, concern for hypotension & bronchoconstriction
CIsatracurium minor histamine release, spontaneous hydrolysis, widely used in surgery, intermediate duration, concern for hypotension & bronchoconstriction
Rocuronium slight cardiac mAChR action, liver elimination, rapid onset for short procedures; alt to succinylcholine
Mivacurium low histamine release, plasma ChE metabolism, brief procedures -alt to succinylcholine
Succinylcholine autonomic ganglia stimulation, slight histamine release, cardiac mAChR stimulation, plasma ChE metabolism, brief procedures - mainly intubation
Created by: ppatel122
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