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Antihistamines/

Mod 5`

QuestionAnswer
How many histamine receptors are there? 4 H1-H4
When are histamines released? allergic and inflammatory response
What is the first agent used to treat allergic reactions? H1 receptor antagonist
What are other uses for H1 receptor antagonist? motion sickness, vestibular disturbances, ?morning sickness
Name first generation H1 receptor antagonist. diphenhydramine, terfenadine, chlorpheniramine, clemastine
2nd generation H1 receptor antagonist. early: loratadine late: cetirizine, fexofenadine
What H1 receptor antagonist has been taken off the market? terfenadine (Seldade) due to QT prolongation had many drug interactions that inhibited metabolism
What H1 receptor antagonist are pregnancy risk category C? Desloratadine (Clarinex) Fexofenadine (Allegra)
What H1 receptor antagonist are pregnancy risk category B? Diphenhydramine loratadine cetirizine
What is the dosage of loratadine? 10mg daily
What drugs inhibit metabolism of loratidine? amiodarone, clarithromycin, ketoconazole, antiretroviral protease inhibitors QT prolongation possible
What is the brand name of loratadine? Claritin
How should loratadine be taken? on an empty stomach
How many days should pt stop taking allergy medications before skin testing? 4 days with loratadine & cetirizine and 1-2 days with fexofenadine
What is the dosage of cetirizine? 5-10mg daily
What is the brand name of cetirizine? Zyrtec
What should cetirizine and fexofenadine not be taken with? grapefruit juice
SALAD of citirizine (Zyrtec)? Xanax, Zantac
What is the dosage of desloratadine? 5mg daily
What is the name brand of desloratadine? Clarinex
What is the brand name of fexofenadine? Allegra
What is the dose of fexofenadine? 60mg BID
What is SALAD of Allegra? Viagra
Created by: Tabble
Popular Pharmacology sets

 

 



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