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AChR Antagonists
Fundamentals II
| Question | Answer |
|---|---|
| Atropine | mAChR Antagonist; reverse muscarine poisoning or AChEI poisoning; long-acting pupil dilation; antidiarrheal |
| Scopolamine | like atropine; motion sickness |
| Tropicamide | short-acting mAChR antagonist; pupil dilation |
| Cyclopentolate | short-acting mAChR antagonist; pupil dilation |
| Homatropine | short-acting mAChR antagonist; pupil dilation |
| Ipratropium | mAChR antagonist (quart. amine; local action); COPD |
| Tiotropium | mAChR antagonist (quart. amine; local action); COPD |
| Tolterodine | mAChR antagonist @ bladder; overactive bladder |
| Dicyclomine | mAChR antagonist in GI; irritable bowel |
| Glycopyrrolate | mAChR antagonist; secretion, sweating, muscarinic overshoot after cholinesterase inhibition |
| Benztropine | lipid soluble mAChR antagonist; extrapyramidal effects (in Parkinson's patients) |
| Mecamylamine | nAChR antagonist; improve GI absorption; Tourette's Syndrome |
| Hexamethonium | nAChR antagonist; Prevents baroreceptor reflex; used in aortic dissection |