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Anti-depressants/

Mod 4 Pharm

QuestionAnswer
Name 3 major categories of anti-depressants 1. tricyclics 2. 2nd/3rd generation 3. SSRI
What percentage of population become depressed during their lifetime? 10%
What two receptors are affected by anti-depressants? antagonism of serotonin and/or noepinephrine
Which anti-depressants has more severe adverse event profile? tricyclics
Name 3 tricyclic anti-depressants 1. amitriptyline 2. doxepin 3. nortriptyline
What is brand name of amitriptyline? Elavil
What is dosage of amitriptyline? 75-200mg daily in divided doses tablet/injection
Which tricyclic antidepressant is a pregnancy risk category D? Nortriptyline (Aventyl)
What is the pregnancy risk category of amitriptyline and doxepin? C
What is the maximum daily dosage of nortriptyline? 150mg/day
What is the major side effect of amitriptyline? significant drowsiness
How long before full effect of amitriptyline is evident? 4 weeks
Can a patient double dose if they miss a dose of amitriptyline? NO. Do not double dose if miss dose of amitriptyline
What is the dosage of doxepin? 75-300mg daily in divided dosage capsule, oral concentrate
What is the SALAD of doxepin? doxycycline (antibiotic)
What should be monitored for in patients who take doxepin? mood changes, suicidal tendencies
What is the dosage of nortriptyline? 25mg tid/qid max daily dose: 150mg/day capsule/oral concentrate
How can a patient avoid daytime sedation when taking nortriptyline? Take full daily dose at bedtime
What is recommended to treat the side effect of dry mouth when taking nortriptyline? sugarless gum or candy
What happens when a pt takes clonipine when on a tricyclic antidepressant? reduced antihypertensive effect
What medications can cause tricyclic toxicity when taken with tricyclic antidepressants? fluoxetine (Prozac-SSRI) paroxetine (Paxil-SSRI)
List 2nd/3rd generation antidepressants 1. bupropion 2. trazadone 3. venlafaxine
What is the name brand of bupropion Wellbutrin Zyban (marketed for smoking cessation)
What is the dosage of bupropion? 100mg bid Max: 400mg tablet, SR
What is the maximum daily dose of bupropion? 400mg
What is the dosage for smoking cessation? 150mg daily x3, incrase to 300mg per day-given as 2 doses 8 hrs apart
What is the pregnancy risk class of bupropion? B
What is a SALAD of bupropion? BusPIRone (BuSpar-antianxiety)
What is a risk associated with alcohol use when taking bupropion? seizures
Is their a suicide risk when taking 2nd/3rd generation anti-depressants? Yes
What is the dosage of trazadone? 150mg daily in divided doses; max outpatient dose 400mg/day
What is the brand name of trazadone? Desyrel
What is thmax daily inpatient dose of trazadone? When hospitalized-up to 600mg
Can trazadone by stopped abruptly? NO
What is the brand name of venlafaxine? Effexor
What is the dosage of venlafaxine? 75mg daily, 2-3 times a day
What is the max daily dose of venlafaxine? 225mg
When should venlafaxine be discontinued? if seizure develop
What is an associated side effect with venlafaxine? sustained increase in blood pressure
What is the pregnancy risk category of venlafaxine? C
What should be monitored if pt taking beta-blocker with 2nd/3rd generation anti-depressant? increase beta-blocker concentration; monitor for bradycardia, hypotension, heart failure
What may happen if pt take MAOI with 2nd/3rd generation anti-depressant? serotonin syndrome
Name SSRIs 1. citalopram 2. fluoxetine 3. paroxetine 4. sertraline
What is the brand name of citalopram? Celexa
What is the daily dose of citalopram? 20mg po daily, increaes to 40mg after no less than 1 week
What is the maximum daily dose of citalopram? 40mg
What are SALADs of citalopram? citalopram (Celexa) DO NOT CONFUSE WITH Celebrex (celecoxib) or Zyprexa (olanzapine)
What is the pregancy risk category of SSRIs? C
What is the brand nameof fluoxetine? Prozac
What is the dosage of fluoxetine? 20mg daily, increase to 20mg in am and mid-day
What is the max dose of fluoxetine? 40mg
Does fluoxetine have a long half-life? Yes (avoid fluoxetine during pregnancy due to long half-life)
Name SALAD of Prozac? Prilosec (omeprazole)
What is the daily dose of paroxetine? 20mg
What is the maximum dose of paroxetine? 50mg
What is the brand name of paroxetine? Paxil
List SALAD of Paxil? Plavix (clopidogrel); Taxol (paclitaxel)
What electrolyte should be monitored in patients taking paroxetine? Sodium hyponatremia may occur
What is the brand name of sertraline? Zoloft
What is the daily dose of sertraline? 25mg increase to 50mg if no improvement in 1 wk.
What is maximum daily dose of sertraline? 200mg
SALAD of Zoloft? Zocor (simvastatin)
What may occur if MAOI takine with SSRI? serotonin syndrome
What drug causes QT prolongation when taking with SSRI? pimozide(antipsychotic)
Created by: Tabble
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