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Muscle relaxants/
Mod 4, Pharm
| Question | Answer |
|---|---|
| What are two uses for muscle relaxants? | 1. paralysis for surgery/intubation 2. reduce spasticity (spasmolytics) |
| Name 3 spasmolytics | 1. carisoprodol (Soma) 2. cyclobenzaprine (Flexeril) 3. methocarbamol (Robaxin) |
| Which spasmolyitics is a pregnancy risk category B? | cyclobenzaprine (Flexeril) |
| What is mechanism of action of carisoprodol? | unknown. thought to be centrally acting |
| What is the dosage of carisoprodol? | 350mg 3-4 times a day, po |
| What is the name brand of carisoprodol? | Soma |
| What class is cyclobenzaprine? | tricyclic antidepressant derivative |
| What is suspected mechanism of action of cyclobenzaprine? | unknown mechanism of action, possilbe at brain stem level |
| What is the pregnancy class of carisoprodol? | C |
| What is dosage of cyclobenzaprine? | 20-40mg daily, divided 2-4 times a day |
| What is the max daily dose of cyclobenzaprine? | 60mg |
| What are the limitations of cyclobenzaprine? | Do not take more than 2 weeks |
| What is the name brand name of cyclybenzaprine? | Flexeril |
| What is the name brand name of methocarbamol | Robaxin |
| What is the mechanism of action of methocarbamol? | carbamate derivative of guaifenesin unknown mechanims, effects related to sedative action |
| What is the pregnancy risk category of methocarbamol? | C |
| What is the dosage of methocarbamol? | 1.5 grams QID for 2-3 days, then 4-4.5 grams daily in 3-6 divided doses Tablet or injection |