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Meds:HTN

Lange, Mod 3

QuestionAnswer
Loop diuretics inhibit NaCl re-absorption in ascending limb of loop of Henle; (inhibit KCl also: hypokalemia) most efficacious
Furosemide Lasix, loop diuretic Pregnancy class: C; not for lactation caution neonates. PO contains sorbitol-can cause diarrhea. Photosensitivity possible
Thiazides inhibit NaCl transport in distal convoluted tubule. carbonic anhydrase activity w/some
Hydrchlorothiazide Hydrodiuril Pregnancy class: B sun-block recommended, take with food, not at night
drug interaction of HCTZ methotrexate toxicity (compete for same transport site in kidneys)
Potassium sparing diuretics antagonist of aldosterone at the late distal tubule & collecting ducts
spironolactone Aldactone Pregnancy risk factor: NR beware of hyperkalemia report mental confusion, lethargy immediately give w/ meals to enhance absorption
drug-drug interaction of potassium sparing diuretic ACE-inhibitors increase hyperkalemia
most common cardiovascular disease hypertension
essential htn no specific cause
Beta-adrenoreceptor blockers atenolol carvedilol
centrally acting sympathoplegic clonidine
Calcium channel blockers verapamil diltiazem
ACE inhibitors lisinopril captopril
Angiotensin Receptor blockers (ARB) candesartan losartan
Tenormin atenolol
Coreg carvedilol
Catapres clonidine
Calan verapamil
Cardizem diltiazem
Prinivil, Zestril lisinopril
Capten captopril
Atacand candesartan
#4 most prescribed medication Atenolol
atenolol (Tenormin) Beta 1 selective blocker drug-drug interaction: cold medicine pregnancy risk: C
carvedilol (Coreg) non-selective beta blocker (w/alpha blocking) beware of SOB pregnancy risk: C
drug-interaction of b-blockers oral hypo-glycemic agents: non-cardioselective beta-blocker increase hypoglycemic response
clonidine centrally acting alpha-adrenergic agonist < cerebral sympathetic outflow inhibit renin release Pregnancy risk: C drug-interaction: TCA (tricyclic antidepressants-< htn effect)
verapamil (Calan) inhibit calcium influx into arterial smooth muscles. Also antianginal, antiarrhytmia Pregnancy risk: C; no breastfeeding report swelling of hands/feet or SOB food increases absorption
diltiazem calcium channel blocker pregnancy risk: C, no breastfeeding drug interaction: pimozide (long QT); grapefruit (increase CCB concentration)
lisinopril ACE inhibitor also for HF, MI pregnancy risk: C; D 2/3 trimesters orthostatic hypotension; caution w/OTC cold meds.
#3 prescribed medication Lisinopril
Captopril ACE inhibitor also with HF Pregnancy:C; D 2/3 trimester(fetal harm/death) Tablet form only; can be given w/diuretic drug interaction: hyperkalemia w other ACEI, hyperkalemia wi potassium sparing diuretic
candesartan (Atacand)ARB Preg risk: C; D 2/3rd trimester food doesn't matter
Losartan ARB preg: C; D in 2/3rd trimester avoid sodium substitutes-hyperkalemia
Created by: Tabble
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