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Meds: Pain
Lange, Mod 3
| Question | Answer |
|---|---|
| Phenanthrenes | morphine hydromorphone codeine oxycodone hydrocodone |
| hydromorphone | Dilaudid |
| oxycodone | Percocet |
| hydrocodone | Lortab, Vicodin |
| Morphine | phenanthrene strong agonist bind to mu receptors in brain/spinal cord Pregancy: C; wait 2-3 hrs before breastfeeding |
| hydromorphone | Dilaudid, phenanthrene bind to receptors on brain/spinal cord as well as act on cough center in medulla Pregnancy class: C |
| hydrocodone | phenanthrene Vicodin, Lortab Pregnancy:C, not recommended w/breastfeeding #1 dispensed medication drug-drug interaction: caustion to not OD with tylenol |
| Phenylheptalamine | Methadone |
| Methadone | Dolophine narcotic analagesic & narcotic detox adjunct Pregnancy class: C |
| Phenylpiperidines | meperidine fentanyl diphenoxylate loperamide |
| meperidine | Demerol, strong opioid (phenylpiperidine) not recommended due to neurotoxic metabolites that can cause seizures, esp in elderly, and renal insufficient also reduces post-op shivering or rigors from amphotericin |
| Morphine dosages | PO: 10-30 mg q 4 hr IV: 2.5-5 mg q 3-4 hr IM/SQ: 5-10mg q 4 hrs |
| Dilaudid dosages | PO: 2-10 mg 3-6 hrs IV/IM/SQ: 2-4mg q 4-6hrs |
| hydrocodone dosages | PO: 5-10 mg q 4-6 hrs |
| Methadone dosages: | pain: 2.5-10 mg PO q 3-4 hrs narcotic abstinence: 15-2- mg po daily |
| Meperidine dosages: | po: 50-150mg q 3-4hrs IM/SQ: 50-75 mg q 3-4 hrs |
| NSAIDS mechanism of action | inhibition of biosynthesis of prostaglandins |
| non-selective cyclooxygenase inhibitors | ibuprofen naproxen meloxicam |
| COX-2 inhibitor | celecoxib |
| COX | cyclooxygenase |
| Platelet aggregation activity of NSAIDS | ASA: irreversible platelet aggregation COX: reversible COX-2: no impact |
| ibuprofen | Advil, Motrin 2400mg daily dose for antiinflammatory dose drug-drug: reduce cardio-protection of ASA Pregnancy class: C; D in 3rd trimester |
| naproxen | Naprosyn non-selective COX inhibitor pregancy risk: C drug-drug: not combine w/ naproxen sodium (anaprox, aleve) Less GI bleed than ASA, but more than ibuprofen |
| Meloxicam | Mobic non-selective COX inhibitor daily dose pregnancy class: C; D in 3rd trimester drug-drug: methotrexate (methotrexate toxicity); warfarin (increase bleeding) |
| Drug-drug interaction of meloxicam | methotrexate warfarin |
| celecoxib | celebrex COX-2 inhibitor pregnancy class:C caution sulfa allergy |
| acetaminophen | analgesic without anti-inflammatory response antipyretic drug-drug: alcohol (liver toxicity); warfarin (increase bleeding) |
| tramadol | Ultram weak synthetic opioid agonist (inhibits norepineprhine and serotonin reuptake) pregnancy: C |
| naproxen dosages | 250-500 mg po BID delayed release: 375-500 mg po BID controlled release: 750-1000mg po daily do not chew or crush DR, CR take with food |
| meloxicam dosages | 7.5-10 mg po daily |
| celecoxib dosages | 100-200 mg PO daily or BID can take with food report SE of swelling, difficulty breathing, yellowing skin |
| tramadol dosages | IR: 50-100 mg po q 4-6 hrs ER: 100-300 mg daily |
Created by:
Tabble
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