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Drugs: CNS
Drugs for CNS/Mental Conditions
| Question | Answer |
|---|---|
| Inter: Valium and Vicodin | CNS depressant synergy |
| Inter: Dilantin (muscle relaxant) and Coumadin | Dilantin decreases Coumadin levels by speeding up liver metab. of coumadin |
| Inter: Diflucan and Abilify | Diflucan increases Abilify levels |
| Inter: Zantac and Antacids/Decongestants/Laxatives | Ant/Dec/Lax interfere with Zantac absorption |
| Inter: MAOIs and Tyramine; Transdermal MAOIs and Tegrotol"T-drugs" | HTN Crisis: H/A, N, increased BP/HR; give Regatin or Procardia |
| Decongestants interfere with 2 drugs... | Zantac and MAOIs |
| SEDATIVE HYPNOTIC ANXIOLYTICS: 3 names, use, imp, OD antidote name | Valium, Lithium, "-ams"; anxiety, alcohol withdrawl; highly dependent, Paradox. Rxn (rage, excit) = STOP!; Ramozicon |
| ATYPICAL/NONBARBITUATE ANXIOLYTICS: 1 N,U,I | buspar; anxiety, broxism/sex.dysf. r/t SSRIs; INTERACTIONS: grapefruit juice, erythromycin, MAOIs, X-zole; BE PATIENT! + SE are self limiting, no dependence! :-) |
| SSRIs: 4NUI | Paxil, Prozac, Lexopro, "-ams", "-ines"; anxiety, depression; Take in AM w/ food, tremors/N/sweat --> insomnia, sexdysf, hyponatremia, weightGAIN; interacts w/ MAOIs, TCAs = serotonin syndrome!; takes a while to see effects |
| TCAs:1+ 5 names | Elavil, SAAST: sinequan, Aventil, Ascendin, Surmontil, Trofavil; take at H.S., increase fluids (2-3L/day+) r/t anticholinergic effects, watch for SEIZURES! |
| 4 drugs that treat Depression are... | TCA,SSRI,MAOI, AtAD |
| 3 drugs that treat Anxiety are... | SHA:Benzos (valium, lithium, "ams"), Atyp/NBA: Buspar, SSRIs: Paxil, "ines", "ams", Lexapro |
| antidote for Opiod OD is... | NALOXINE |
| antidote for Benzo OD is... | RAMAZICON |
| TCAs are contraindicated in these 5 situations: | 1) CAD 2) BPH 3) DM 4)A-C Gloucoma 5)hyperthyroidism |
| 2 paths to SEROTONIN SYNDROME | 1) SSRIs + MAOI, TCA, St Johns Wart 2) TCAs + MAOI, St Johns Wart |
| 3 drug interactions of Prozac/Fluoxitine | 1)increases Coumadin/ PT 2) increase TCA 3)increase Lithium |
| 2 SSRIs that increase birth defect risk | Prozac and Paxil |
| MAOIs: 4nui | Nardil, Morplant,Parnate, Emsam (TD-not with "Tdrugs"; Atyp Depression, Bulimia Inter: demerol, decong., cold meds, tyramine; OH, HTN crisis(HA/N/BP&HR up) |
| 2 drugs that treat BULIMIA | SSRI Prozac; MAOIs |
| ATYPICAL ANTIDEPRESSANTS: 6 NUI | Wellbutrin + CERED: cymbalta(skinny, with low NA and high DBP), effexor, Remeron(SSRI replacer),edronax,desyrel(desires a friend: w/ SSRI for insomnia) |
| Inter: Valium and Vicodin | CNS depressant synergy |
| Inter: Dilantin (muscle relaxant) and Coumadin | Dilantin decreases Coumadin levels by speeding up liver metab. of coumadin |
| Inter: Diflucan and Abilify | Diflucan increases Abilify levels |
| Inter: Zantac and Antacids/Decongestants/Laxatives | Ant/Dec/Lax interfere with Zantac absorption |
| Inter: MAOIs and Tyramine; Transdermal MAOIs and Tegrotol"T-drugs" | HTN Crisis: H/A, N, increased BP/HR; give Regatin or Procardia |
| Decongestants interfere with 2 drugs... | Zantac and MAOIs |
| SEDATIVE HYPNOTIC ANXIOLYTICS: 3 names, use, imp, OD antidote name | Valium, Lithium, "-ams"; anxiety, alcohol withdrawl; highly dependent, Paradox. Rxn (rage, excit) = STOP!; Ramozicon |
| ATYPICAL/NONBARBITUATE ANXIOLYTICS: 1 N,U,I | buspar; anxiety, broxism/sex.dysf. r/t SSRIs; INTERACTIONS: grapefruit juice, erythromycin, MAOIs, X-zole; BE PATIENT! + SE are self limiting, no dependence! :-) |
| SSRIs: 4NUI | Paxil, Prozac, Lexopro, "-ams", "-ines"; anxiety, depression; Take in AM w/ food, tremors/N/sweat --> insomnia, sexdysf, hyponatremia, weightGAIN; interacts w/ MAOIs, TCAs = serotonin syndrome!; takes a while to see effects |
| TCAs:1+ 5 names | Elavil, SAAST: sinequan, Aventil, Ascendin, Surmontil, Trofavil; take at H.S., increase fluids (2-3L/day+) r/t anticholinergic effects, watch for SEIZURES! |
| 4 drugs that treat Depression are... | TCA,SSRI,MAOI, AtAD |
| 3 drugs that treat Anxiety are... | SHA:Benzos (valium, lithium, "ams"), Atyp/NBA: Buspar, SSRIs: Paxil, "ines", "ams", Lexapro |
| antidote for Opiod OD is... | NALOXINE |
| antidote for Benzo OD is... | RAMAZICON |
| TCAs are contraindicated in these 5 situations: | 1) CAD 2) BPH 3) DM 4)A-C Gloucoma 5)hyperthyroidism |
| 2 paths to SEROTONIN SYNDROME | 1) SSRIs + MAOI, TCA, St Johns Wart 2) TCAs + MAOI, St Johns Wart |
| 3 drug interactions of Prozac/Fluoxitine | 1)increases Coumadin/ PT 2) increase TCA 3)increase Lithium |
| 2 SSRIs that increase birth defect risk | Prozac and Paxil |
| MAOIs: 4nui | Nardil, Morplant,Parnate, Emsam (TD-not with "Tdrugs"; Atyp Depression, Bulimia Inter: demerol, decong., cold meds, tyramine; OH, HTN crisis(HA/N/BP&HR up) |
| 2 drugs that treat BULIMIA | SSRI Prozac; MAOIs |
| ATYPICAL ANTIDEPRESSANTS: 6 NUI | Wellbutrin + CERED: cymbalta(skinny, with low NA and high DBP), effexor, Remeron(SSRI replacer),edronax,desyrel(desires a friend: w/ SSRI for insomnia) |
| ATYPICAL ANTIDEPRESSANTS: Wellbutrin | smoking cessation; SE: HA, GI/constipated, insomnia, WEIGHTLOSS/LESS APPETITE; |
| 2 Nervous system drugs that cause constipation | TCAs, AtAD |
| AtAD:Remeron | SSRI replacer: faster working, less sexual SEs, well tolerated BUT sleepiness, WEIGHTGAIN, HIGH CHOLESTEROL; DON'T DRINK ALCOHOL! |
| AtAD: Desyrel | "desires a friend": TX SSRI insomnia, if PRIAPISM, get help ASAP! |
| SSRI summary facts | in am w/ food to decrease sleep disturbances; causes WEIGHTGAIN and SEX SEs. |
| MAOI summary facts | causes OH, list of tyramine rich foods to avoid HTN crisis; interact with vasopressors/caffiene;chromo....(adrenal tumor) |
| Which Nervous system drugs helps treat enuresis and chronic pain? | TCAs! :-) |
| Buproprion HCL/Wellbutrin (AtAD) summary facts | meds autumn - spring and taper off |
| TCA summary facts | take at HS; Anticholinergic SEs;extra fluids!; constipation and seizures watch! |
| CNS drugs that decrease seizure threshold | TCAs |
| Wellbutrin _______s weight, while Remeron ____s weight | decreases; increases |
| 3 CNS drugs w/o sexual SEs | MAOIs (nardil), TCAs (elavil), AtAD (Remeron- "sleepy and fat, but having good sex") |
| 2 CNS drugs that cause OH | TCAs, MAOIs |
| Sxs of SEROTONIN SYNDROME | agitated, confused, disorient., cant concentrate, anxious. HYPEREFLEXIA, TREMORS, hallucinations,FEVER, sweating; onset is 2-72 hrs, treatment is to DIC therapy! |
| Prozac is for______, Paxil is for________ | anxiety; depression |
| 2 meds contraindicated for diabetics | AtypAntiPsych: Risperdol/abilify/seroquel/clozapine TCAs: Elavil |
| CNS Meds that cause HYPOnatremia | SSRIs, Cymbalta (AtAD) |
| increase fluids with these 2 CNS meds | TCAs, Conventional Antipsychs (Thorazine, Haldol) |
| CNS Meds that increase cholesterol | Remeron (AtAD) and Risperdol (AtAP) |
| Meds used to treat Schizophrenia | Conventional APs (+): Thorazine, Haldol; AtypAPs (+ & -): Risperdol (and Sero/Abil/Clozapine/Zeprexa) |
| Conv APs: uses and schedule of 4 SEs to watch for | everything + dimentia, tourettes, N/V stopper!; 1)AD-head spasms @ hrs-days-CRISIS = cogentin, benadryl 2)Parks- shuffle @ 1mo 3) pacing @ 2 mo 4) LATE EPS: lipsmack @ 1 yr(s) |
| Increase fluids and take at H.S. when on these 2 CNS meds: | TCAs and Conventional APs :-) |
| Emergency SE of ConvAPs and Tx | NeuroMaligSyndrome: (highgrd fever, rigmuscles, BP??, Dysrhyth; to tx, STOP MED! and give VALIUM and DANTRIUM |
| The long list of ConvAP SEs | AGRANULOCYTISIS, sleepiness, SexDysf (ssri), temp. OH (tca, maoi), cholinergic effects, big boobs, menstrual screwups |
| ConvAPs fact summary | BID--> H.S.; increase fluids, watch for ADVERSE effects, significant improvement may take 2-4 wks. |
| ATYPICAL ANTIPSYCH DRUGS: 5 N,u | Risperdol, seroquel, abilify, clozapine (YES antichol SEs), zeprexa; + and - sxs of schizo!!, psychosis r/t levadopa or anything else too! |
| AtypAPs: contras, SE | Contraindicated in dimentia, DM (like TCA); SE: weightgain (like SSRI, Remeron), increased cholesterol (like Remeron), EPS, Diabetes (can cause it!), CATARACTS, "torsades-d-pointes" = VT-> VF |
| AtypAPs: 3 drug interactions | Interacts with: immuno-supressor drugs, TCAs (and others that lengthen the QT interval), Barbituates |
| Clovapine: the "wierd" AtypAP | PO only; causes AGRANULOCYTOSIS like Coventional APs, no longer the first line drug for Schizo |
| Drug interactions for Thorazine/Haldol | Levadopa!,alcohol, opiods, antihistamines (like w/ MAOIs) |
| Neurontin_____ migraines, while Depakote______s migraines. | "NO"/prevents; "Diminishes"/treats |
| AGRANULOSYTOSIS is a SE of these 2 CNS meds: | ALL Conventional APs, Clozapine |
| Tegretol (seizure med)3 characteristic SEs are: | blood dyscrasias, fluid overload in CHF pts, skin disorders |
| Valproic Acid (Depakote)'s 5 main SEs (also increases Dilantin levels!) | THROMBOCYTOPENIA,N/V, indigestion, hepatotoxicity, pancreatitis |
| Dilantin (and Tegretol) DECREASES effects of (3), and is DECREASED by (3) | DECREASES: (PO CONTRAS., COUMADIN!); is DECREASED by: chronic alcoholism, phenobarbital, carbamazipine (weird AtypAP) |
| ER Adverse Reaction to General Anesthetics: | MALIGNANT HYPERTHERMIA:rigid muscles+ HOT body (up to 109 F!); ADMIN. DANTROLINE! (antidote) |
Created by:
ajkrudy
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