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  Normal Size     Small Size show me how ANTIDEPRESSANTS for PT

State the mechanism of action of the SNRIs: inhibit reuptake of serotonin & norepinephrine into CNS nerve terminals
List the SNRI antidepressants: duloxetine (Cymbalta), venlafaxine (Effexor), desvenlafaxine (Pristiq)
List the side effects of SNRIs: insomnia, nervousness, sexual dysfunction, serotonin syndrome, physical dependence/withdrawal symptoms, dry mouth, anorexia, CV effects (HTN, tachycardia)
State the mechanism of action of the SSRIs: inhibit reuptake of serotonin into CNS nerve terminals
List the SSRI antidepressants: fluoxetine (Prozac), sertraline (Zoloft), citalopram (Celexa), paroxetine (Paxil)
List the side effects of the SSRIs: insomnia, nervousness, sexual dysfunction, serotonin syndrome, physical dependence/withdrawal symptoms
State the mechanism of action of the TCAs: inhibit reuptake of serotonin, norepinephrine, & dopamine into CNS nerve terminals
List the TCA antidepressants: amitriptyline (Elavil) is the one I asked you to know
List the side effects of the TCAs: drowsiness, sedation, sexual dysfunction, physical dependence/withdrawal symptoms, anticholinergic side effects, CV effects (HTN & tachycardia), orthostatic hypotension
State the mechanism of action of the MAO-inhibitors: inhibit breakdown of serotonin, norepinephrine, & dopamine in the CNS nerve synapses and inhibit tyramine breakdown in intestines
This SNRI is specifically FDA approved to treat fibromyalgia pain: duloxetine (Cymbalta)
Which class of antidepressants has the LEAST cardiac effects? SSRIs (The TCAs & SNRIs have more because they both affect norepinephrine)
Which class of antidepressants is most likely to cause orthostatic hypotension, sedation, & anticholinergic side effects? TCAs
Which class of antidepressants is most likely to worsen dementia? TCAs
List symptoms of serotonin syndrome hypo/hypertension, agitation, muscle tightness & twitching, hyperthermia, shivering, tachycardia & other arrhythmias, seizures, coma and death
List the general therapeutic uses of the antidepressants: anxiety (generalized anxiety, phobic disorders, obsessive compulsive disorder), premenstrual dysphoric disorder, bulimia, Tourette's syndrome, bipolar disease, neuropathic pain (diabetic peripheral neuropathy pain, post-herpetic neuralgia/shingles pain)
This antidepressant causes sedation (take at bedtime): trazodone (Desyrel) and mirtazepine (Remeron) and all the TCAs
Which antidepressants have life-threatening food interactions? MAO-inhibitors (tyramine containing foods)
This antidepressant is used for smoking cessation: bupropion (Wellbutrin, Zyban)
This antidepressant can be problematic for older men with BPH: TCAs (because of their anticholinergic side effects – urinary retention)
This antidepressant causes weight gain and drowsiness as side effects (take at bedtime): mirtazepine (Remeron)
About how long does it take for antidepressants to take effect? several weeks (3 – 4 weeks)
Are antidepressants addictive? No, antidepressants do not cause psychological dependence. However, they can cause physical dependence and withdrawal symptoms so should not be stopped suddenly
Describe the general treatment for generalized anxiety disorders: daily antidepressant (buspirone) with or without a prn benzodiazepine for acute/breakthrough anxiety
This drug is used specifically for anxiety only and is NOT an antidepressant or benzodiazepine: buspirone (Buspar)



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