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NTI

Narrow Therapeutic Index Drugs

Drug NameBrandTC/IndTherapeutic Range
Cyclosporine Gengraf, Neoral, Sandimmune Calcineurin inhibitor/immunosuppression, transplant, RA, lupus, colitis, refractory plaque psoriasis ~100-400 (nephrotoxicity possible at any level)
Ethosuximide Zarontin Succinimide anticonvulsant/absence (petit mal) seizures 40-100
Levothyroxine Levothroid, Levoxyl, Synthroid, Unithroid Thyroid product/Hypothyroidism, people in need of TSH suppression [thyroid cancer, goiter], myxedema coma or stupor ~4-12 (High >13.1)
Lithium Lithobid Antimanic agent/Bipolar disorder (mania) ~0.6-1.2 (Toxic >1.5)
Phenytoin Dilantin Hydantoin anticonvulsant/status epilepticus, anticonvulsant, neurosurgery prophylaxis Total: 10-20 (Toxic >30, Lethal >100) Free: 1-2.5
Procainamide HCl (No US brand) Class Ia antiarrhythmic/Arrhythmias 4-10 (Toxic >10-12) (NAPA: 15-25; Combined: 10-30)
Theophylline Theochron (Itself-derivative)/Asthma exacerbations, COPD treatment 5-15
Warfarin Coumadin Vit K antagonist/Prevent or treat thrombosis or embolism N/A (normal PT [2-3x control] and INR [2-3 or 2.5-3.5])
Carbamazepine Tegretol Miscellaneous Anticonvulsant/Bipolar disorder, trigeminal neuralgia, epilepsy 4-12 (Toxic >15)
Digoxin Lanoxin Cardiac glycoside/Rate control in arrhythmias and HF Adults: <0.5 HF: 0.5-0.8 (Toxic >2)
Created by: dfernand
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