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Pharmaceutic
Pharmaceutic Test #1
| Question | Answer |
|---|---|
| Solubility | the concentration of a dissolved solute in a saturated solution in contact with the solid solute at a given temperature |
| Thermodynamic Solubility | maximum concentration of the stable crystalline form of a drug in a given solvent under equilibrium |
| Stable crystalline form | one with the lowest solubility and lowest energy state |
| Unsaturated solution | a solution containing the dissolved solute in a concentration less than a saturated solution |
| Supersaturated solution | solution that contains more of the dissolved solute than which exists at equilibrium at the given temperature |
| Very soluble | <1 |
| Freely soluble | 1 to 10 |
| Soluble | 10 to 30 |
| Sparingly soluble | 30 to 100 |
| Slightly soluble | 100 to 1000 |
| Very slightly soluble | 1000 to 10000 |
| Pratically insoluble | > 10000 |
| N-pentane | 14.4 |
| N-hexane | 14.9 |
| Diethyl ether | 15.4 |
| Ethyl acetate | 18.2 |
| Chloroform | 18.7 |
| Acetone | 19.7 |
| Ethanol | 26.2 |