Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Parkinsons treatment

QuestionAnswer
At what age does Parkinsons disease usually begin? between 45-65 years old
what are the common symptoms associated with parkinsons disease tremors, rigidity, bradykinesia, postural and gait abnormalities
Is mental capacity affected by Parkinsons? No, facial expression is affected
Due to affected facial expression in pt. with Parkinsons, what symptoms may occur less blinking, reduced facial expressions, drooling, impaired swallowing, soft and difficult annunciation
What is the cause of parkinsons disease in terms of physiological function decrease of inhibitory dopaminergic neurons causing an imbalance between dopamine/acetylcholine
How is Parkinsons disease treated? cannot stop degeneration of dopaminergic neurons of reverse the disease but can relieve symptoms by increasing dopamine levels while blocking effects of ACh
what is the MoA of levodopa/carbidopa? levodopa is converted to dopamine in CNS by dopaminergic neurons and once they run out of active neurons they cannot convert the drug Carbidopa blocks peripheral conversion of levodopa to dopamine, but carbidopa itself does not cross BBB
What are some of the adverse effects of levodopa/carbidopa N/V, constipation, Ortho hypotension, cardia dysrhythmias, restlessness, insomnia, confusion, pychihatric disturbances, dyskinesias (chorea, athetosis, dystonia, tremor, tics, myoclonus), on-off phenomenon (abrupt fluctuations in severity of symptoms)
What is the on-off phenomenon abrupt transient fluctuations in severity of symptoms specific to levodopa/carbidopa: Bradykinesia/dyskinesias seen after long term therapy
What are the common Drug interactions with levodopa/carbidopa? Dopamine blockers worsen Parkinsons, Antipsychotics (1st gen. antipsych) produce parkinsonian symptoms
what drugs block dopamine receptors in vomit center of CNS and therefore interact negatively with levedopa/cabidopa antiemetics (Reglan and Compazine, phenergan)
What are the common COMT-inhibitors (Catechol Omethyltransferase Inhibitors? entacapone (Comtan), levodopa, carbidopa, entacapone (Stalevo)
What is the MoA of COMT-inhibitors target metabolizer of levodopa, COMT
What is the therapeutic use of COMT-inhibitors combined w/ levadopa/cardopa to reduce on/off phenomenon and more sustained/consistent CNS dopamine levels
What are the adverse effects of COMT-inhibitors Peripheral and CNS domaninergic AE and diarrhea and hallucinations
What are teh common dopamine receptor agonists Ropinirole (Requip) & Pramipexole (Mirapex)
what is the MoA for Dopamine receptor agonists? to directly stimulate dopamine receptors
Which drug is FDA approved for restless leg syndrome Dopamine receptor agonists - Pramipexole (Mirapex) and Ropinirole (Requip)
What are the most common Monoamine Oxidase-B inhibitors used? Selegiline (eldepryl, Zelapar)
What is the MoA for Monoamine Oxidase-B inhibitors selectively inhibits enzyme that breaks down dopamine (MAO-B), so it increases the levels of dopamine, but does not inhibit breakdown of norepinephrine, serotonin, and tyramine (moa-a)
What is the difference between MOA-Inhibitors and MOB-Inhibitors? MOB-inhibitors do not have food/drug interactions like MOA-I, but at higher doses they lose their selectivity
What is the most common Adverse Effect of MOB-I? insomnia
What drugs interact with MOB-Is dextromethorpha, pseudophedrine, tramadol, and meperidine
What is the MoA of Amantadine (symmetrel) antiviral agent that enhances synthesis, release, or re-uptake of dopamine
what is the therapeutic use of amantadine treats mild symptoms of Parkinson's disease and respiratory flu but is less effective than levodopa and tolerance is more rapid
How is Benztropine used to treat Parkinsons disease? it is an anticholinergic agent that antagonizes ACh and treats mild parkinsons
Which drug is used alone in MILD Parkinsons disease but usually used with dopamine active meds? Anticholinergic Agents
Which Anticholinergics are most commonly used to treat antipsychotic EPSE Benztropine
Created by: aamoore2245
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards