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Mod 4 PT Final

QuestionAnswer
A tablet that releases one dose immediately and then releases a second dose sometime later is a ---- tablet. modified release
Drugs can pass through biological membranes Through aqueous pores, by active transport, and by passive diffusion (all of the above)
Extended agonist stimulation leads to a Decrease number of receptors
Bioequivalency is determined by comparing the ---- two products bioavailabilities
In the blood concentration-time profile, the duration of action can be measured as the time from when blood concentrations first reaches the MEC to when the declining blood concentrations reaches then falls below the MEC
Levofloxacin has been shown to bind to calcium, magnesium, and aluminum ions and decrease the bioavailability of levofloxacin. What type of drug-drug interaction is this? complex formation
What criteria should not be used to determine drug dosages for infants? age alone
Which is not a mechanism of drug action? changes in metabolism, chemical reaction, and protective/physical. (all of the above)
Interactions that alter drug absorption can be minimized by separating the administration of the drug and food intake by: 2 hours
Which route of administration does not have an absorption step? intravenous
When a drug is displaced from serum protein by a stronger binding drug the amount of drug A will increase the amount of free drug A
The ---- is the blood concentration needed to produce a response. Minimum effective concentration (MEC)
As blood concentrations fall in a blood concentration-time profile ---- is the predominant process distribution and metabolism
Extended antagonist stimulation leads to a increased number of receptors
When drug molecules are bound to plasma or tissue proteins they are inactive
Pharmaceutical alternatives have the same active ingredient, different salt form of the active ingredient and different dosage forms. (all of the above)
Drugs bind to many proteins, plasma proteins drug remains biologically inactive
Elderly patients may experience more drug interactions than other populations because all of the above
Which is not a means of losing orally administered drug? administer a solution
most drugs given orally are absorbed into the blood from the small intestine
The percentage or fraction of an administered dose of a drug that actually reaches the systemic circulation and the rate at which this occurs is the drug's bioavailability
To avoid first-pass metabolism, administer the drug by a parenteral route
---- occurs when two drugs with similar pharmacological actions result in effect equal to the sum of their individual affects. additive effect
most drugs given orally are absorbed into the blood from the small intestine
Glomerular filtration is the blood filter process of the kidney
What would not be responsible for increased drug bioavailibility in hepatic disease? increased first pass effect
in metabolism, the breakdown of drugs into metabolites is caused by enzymes
When a drug binds to a receptor and affects the normal cellular process, it is an agonist
the place where a drug causes an effect to occur is site of action
which set of circumstances will result in a drug undergoing urinary excretion but not urinary re-absorption? basic drug in low pH urine
which physiological change occurs during pregnancy? decreased gastric emptying
First-pass metabolism refers to the substantial degradation of the drug caused by enzyme metabolism in the liver
Bioavailability measures rate and extent the drug is available to the site of action
most drugs and their metabolites are excreted by the kidneys
what does first pass metabolism have on drug absorption? decrease absorption
Which is generally a characteristic of a Type A ADR dose-dependent
Spinach and other green vegetables contain vitamin ---- that inhibits the action of oral anticoagulants K
Tissue protein acts as a depot for the drug
Created by: Talk2thispinoy
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