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Stack #65053

Cholinergic and Cholinesterase Inhibitors

QuestionAnswer
What receptor does the direct acting Cholinergic agonist use? Muscarinic
What receptor does the indirect acting Cholinergic agonist or AChEI use? Nicotinic
What chemical substances make up direct acting cholinergic drugs? Naturally occuring alkaloids, or synthetic choline esters
What chemical characteristics make up indirect acting and/or AChEI's, what doe they do? They can be reversible or irreversible, they increase ACh concentrations
The M1 muscarinic receptor, location and secondary messenger? Nerves/CNS and and increase in IP3 and DAG - through Gq
The M3 muscarinic receptor, location and secondary messenger? Eyes,glands,smooth muscle and endothelium(blood vessels) and increase in IP3 and DAG - through Gq
The M2 muscarininc receptor, location and secondary messenger? Found in the heart(vagal effect), nerves - reduces AC which reduces cAMP, opens up K channels in heart
Created by: BlueEntity
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