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JGR-Muscle Relaxants

QuestionAnswer
List the muscle relaxant drugs used to treat spasticity (CNS Disturbances: MS, Cerebral Palsy,higher motor neuron syndromes, strokes) Baclofen (Lioresal®) Dantrolene sodium (Dantrium®) Diazepam (Valium®) – BCF Tizanidine (Zanaflex®)
List the muscle relaxant drugs that are for local musculoskeletal spasms (spasmolytic) Methocarbamol (Robaxin®) - BCF Orphenadrine (Norflex®) Metaxalone (Skelaxin®) Carisoprodol (Soma®) Gabapentin (Neurontin®) & Tiagabine (Gabitril®) Botulinum toxin (type A - Botox®, type b - Myobloc®) Cyclobenzaprine (Flexeril®) – BCF
What is the common side effect across all muscle relaxants? Drowsiness
Which spasmolytic drug has a chemical structure and properties (CNS active) similar to tricyclic antidepressants? Cyclobenzaprine (Flexeril®) – BCF
Which spasmolytic drug has anti-muscarinic properties (Anti-slude)? Cyclobenzaprine (Flexeril®) – BCF
Which spasmolytic drug discolors the urine brown? Methocarbamol (Robaxin ®)– BCF
What is the advantage of Methocarbamol (Robaxin®)? Rapid onset
What form does Methocarbamol (Robaxin®) come in? Tabs and Injection
Which anti-spasticity drug is a centrally acting alpha-2 agonists? Tizanidine (Zanaflex®)- Congener of Clonidine
What are the main side effects of Tizanidine (Zanaflex®)? drowsiness and hypotension
Which spasmolytic drug is a cousin of Diphenhydramine (Benedryl®) ? Orphenadrine (Norflex®)
Which two spasmolytic drugs are anticholinergics? Cyclobenzaprine (Flexiril®) and Orphenadrine (Norflex®)
Which spasmolytic drug is sometimes mixed with caffeine? What is the combo med called? Oprhenadrine (Norflex®) Norgesic Forte®
Which spasmolytic drug is known to cause the least drowsiness? Metaxalone (Skelaxin®)
Which spasmolytic drug is metabolized into methrobamate (controlled substance for anxiety)? Carisoprodol (Soma®)
What are the two typical combination drugs of Carisoprodol (Soma®)? Soma ®+ Aspirin Soma ®+ Codeine + Acetaminophen (Tylenol®)
Which anti-spasticity drug is also used for anti-anxiety and stops seizures and works on GABA-A receptor? Diazepam (Valium®)
Which anti-spasticity drug works on GABA-B receptor? Baclofen (Lioresal®)
What is the Anti-spasticity drug specifically indicated for MS? Baclofen (Lioresal®)
What are the main side effects of Baclofen (Lioresal®)? Abrupt withdrawal=seizures Wide array of central nervous system effects (Nausea, confusion, euphoria, depression)
How is Baclofen (Lioresal®) administered? Tabs Intrathecal Injection
What is the only direct acting anti-spasticity drug? Dantrolene Sodium (Dantrium®)
What is the drug of choice for malignant hyperthermia? Dantolene Sodium (Dantrium®)
What are the indications for Botulinum Toxin (Botox®)? Cervical dystonias Dynamic muscle contractures in CP Blepharospasm
What drugs are anti-epileptics used for muscle spasms and neuropathic pain ? Gabapentin (Neurontin®) & Tiagabine (Gabitril®)
Created by: joannasan
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