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Adrenergic Nerv Syst
www.pharmteacher.com Adrenergic Nerv Syst Receptor, Location, & Effect
| What receptor is found here? | Mostly this type of receptor | What happens? | Physiological Response | Physiological Response | |
|---|---|---|---|---|---|
| For best results click each card 6 times to see ALL the related material. | First you will see the organ or tissue. | Click to see the type of receptor most prevalent there. | You will be asked what happens when those receptors are stimulated. | Next, you will be asked what happens when those receptors are blocked. | Sometimes, additional info is also given. |
| Lungs (Bronchioles) | mostly B2 | What happens when these receptors are stimulated? | BronchoDILATION... The body needs MORE oxygen in a fight/flight situation. E.g. albuterol is a B2 agonist | What happens when these receptors are blocked? | BronchoCONSTRICTION... Chest tightness, difficulty breathing. |
| Vasculature of Skin and Mucous Membranes | mostly A1 | What happens when these receptors are stimulated? | VasoCONSTRICTION... Increased BP. Why? Body wants to shunt blood away from nonessential areas (e.g. skin) and to heart & muscles. Skin is the largest body organ thus LOTS of vasoconstriction occurs. | What happens when these receptors are blocked? | VasoDILATION... Reduced BP. E.g. alpha 1 blockers reduce BP. |
| Liver | mostly B2 | What happens when these receptors are stimulated? | Glycogenolysis... Increased liver production of glucose. The body need energy in a fight/flight situation. | What happens when these receptors are blocked? | Liver will be less able to produce glucose. Can prolong episodes of hypoglycemia so be careful in a patient with diabetes. |
| Uterus | mostly B2 | What happens when these receptors are stimulated? | Reduced uterine contractions... Why? You don't want to go into labor during a fight/flight situation, right? | What happens when these receptors are blocked? | May stimulate uterine contractions... This could induce early labor in a pregnant woman. |
| Urinary Tract (Bladder Muscle and Urinary Sphincter) | mostly A1 | What happens when these receptors are stimulated? | Urinary retention... Difficulty urinating. You don't want to have to stop and pee in a flight/fight situation. | What happens when these receptors are blocked? | Urinary incontinence... Loss of bladder control. |
| Presynaptic Nerve Terminals | mostly A2 | What happens when these receptors are stimulated? | Reduction of further norepinephrine release... This is how the body "shuts off" the adrenaline output. E.g. alpha2 agonists lower BP. | What happens when these receptors are blocked? | Increased release of norepinephrine |
| Pupil of the Eye | mostly A1 | What happens when these receptors are stimulated? | Mydriasis (pupil dilation)... Not useful to know medically, but when you are sexually aroused, you release adrenaline and your pupils dilate. | What happens when these receptors are blocked? | Miosis (pupil constriction) |
| Heart | mostly B1 | What happens when these receptors are stimulated? | Increased HR (tachycardia) and increased force of cardiac contraction (positive inotrope) | What happens when these receptors are blocked? | Decreased HR (bradycardia) and decreased force of cardiac contraction (negative inotrope) |
| Vasculature of Skeletal Muscle | mostly B2 | What happens when these receptors are stimulated? | VasoDILATION... Why? We need to Increase blood flow to muscles in fight/flight situation. Yes this could decrease BP but remember if A1 receptors are also being stimulated, overall BP will go up. (Body has more skin than muscle) | What happens when these receptors are blocked? | VasoCONSTRICTION... Blood flow to muscles is reduced. |
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